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Customisable 3D printed microfluidics for integrated analysis and optimisation

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posted on 05.08.2016 by Tom Monaghan, Matthew Harding, Russell A. Harris, Ross J. Friel, Steven Christie
The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100–500 μm) means that these devices were capable of handling a wide range of concentrations (9 μM–38 mM), and are ideally suited to both analyte detection and process optimisation. This ability to tailor the chip design and its integrated features as a direct result of the reaction being assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device and reaction. As a result of the information gained in this investigation, we are able to report the first instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded optical fibres capable of performing UV-vis spectroscopy directly inside micro channels.

Funding

This work was supported by the Engineering and Physical Science Research Council (EPSRC) via the Centre for Innovative Manufacturing in Additive Manufacturing.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Lab On a Chip: microfluidic and nanotechnologies for chemistry, biology, and bioengineering

Citation

MONAGHAN, T. ...et al., 2016. Customisable 3D printed microfluidics for integrated analysis and optimisation. Lab On a Chip, 16 (17), pp. 3362-3373.

Publisher

© Royal Society of Chemistry

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

18/07/2016

Publication date

2016

Notes

This paper was accepted for publication in the journal Lab On a Chip and the definitive published version is available at http://dx.doi.org/10.1039/C6LC00562D.

ISSN

1473-0197

Language

en

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