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Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity?

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journal contribution
posted on 12.05.2020 by Maooz Awan, Iryna Buriak, Roland Fleck, Barry Fuller, Anatoliy Goltsev, Julie Kerby, Mark Lowdell, Pavel Mericka, Alexander Petrenko, Yuri Petrenko, Olena Rogulska, Alexandra Stolzing, Glyn N Stacey
Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bone marrow and blood cells until needed for transfusion. Nevertheless, its effects on cell biology and apparent toxicity in patients have been an ongoing topic of debate, driving the search for less cytotoxic cryoprotectants. This review seeks to place the toxicity of DMSO in context of its effectiveness. It will also consider means of reducing its toxic effects, the alternatives to its use and their readiness for active use in clinical settings.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Regenerative Medicine

Volume

15

Issue

3

Pages

1463 - 1491

Publisher

Future Medicine

Version

VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

27/03/2020

Publication date

2020-04-28

Copyright date

2020

ISSN

1746-0751

eISSN

1746-076X

Language

en

Depositor

Prof Alexandra Stolzing. Deposit date: 12 May 2020

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