Distribution of ApoE Variants in Four Northeast Distribution of ApoE Variants in Four Northeast Indian populations.pdf (168.67 kB)
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Distribution of APOE variants in four Northeast Indian populations

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posted on 23.03.2017 by Albeliz Santiago-Colon, Rebekah Karns, Sarabjit Mastana, Karns Ranjan Deka
Polymorphisms in the human apolipoprotein E gene (ApoE) have been extensively studied for associations with various complex diseases. Numerous population genetic studies have reported the distribution of ApoE alleles in global populations. In this study, we present new data on the distribution of ApoE polymorphisms among four Northeast Indian populations, namely, Kachari, Rabha, Ahom, and an Indo-European caste group. Allele frequencies, Hardy-Weinberg equilibrium, genotype and phenotype probabilities were based on the two SNPs, rs7412 and rs429358. Of the APOE genotypes, derived from rs429358 and rs7412 SNPs, 3/3 and 3/4 genotypes were the most frequent in all groups and only Rabha showed higher frequency of 2/3 genotype. The Kachari population showed the highest frequency of CT genotype for SNP rs429358 and the highest frequency of allele *E4 in the Indian subcontinent, which was much higher than other study populations of eastern India.

History

School

  • Sport, Exercise and Health Sciences

Published in

Collegium Antropologicum

Volume

40

Issue

4

Pages

285 - 289 (5)

Citation

SANTIAGO-COLON, A. ...et al., 2017. Distribution of APOE variants in four Northeast Indian population. Collegium Antropologicum, 40(4), pp. 285-289.

Publisher

Croatian Anthropological Society

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

30/11/2016

Publication date

2017

Notes

This is an Open Access Article. It is published by Croatian Anthropological Society under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Unported Licence (CC BY-NC-ND). Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/4.0/

ISSN

0350-6134

Language

en

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