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Effect of acute exercise and hypoxia on markers of systemic and mucosal immunity

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journal contribution
posted on 12.08.2016 by Ida Svendsen, Erlend Hem, Michael Gleeson
Purpose To determine how immune markers are affected by acute hypoxic exercise at the same relative intensity. Methods Twelve endurance-trained males (age: 28 ± 4 years, V˙V˙ O2max: 63.7 ± 5.3 mL/kg/min) cycled for 75 min at 70 % of altitude-specific V˙V˙ O2max, once in normoxia (N) and once in hypobaric hypoxia equivalent to 2000 m above sea-level (H). Blood and saliva samples were collected pre-, post- and 2 h post-exercise. Results Participants cycled at 10.5 % lower power output in H vs. N, with no significant differences in heart rate (P = 0.10) or rating of perceived exertion (P = 0.21). Post-exercise plasma cortisol was higher in H vs. N [683 (95 % CI 576–810) nmol/l vs. 549 (469–643) nmol/l, P = 0.017]. The exercise-induced decrease in CD4:CD8 ratio was greater in H vs. N (−0.5 ± 0.2 vs. −0.3 ± 0.2, P = 0.019). There were no significant between-trial differences for adrenocorticotropic hormone, plasma cytokines, antigen-stimulated cytokine production, salivary immunoglobulin-A or lactoferrin. However, there was a main trial effect for concentration [F(11) = 5.99, P < 0.032] and secretion [F(11) = 5.01, P < 0.047] of salivary lysozyme, with this being higher in N at every time-point. Conclusion Whether the observed differences between H and N are of sufficient magnitude to clinically impair host defence is questionable, particularly as they are transient in nature and since other immune markers are unaffected. As such, acute hypoxic exercise likely does not pose a meaningful additional threat to immune function compared to exercise at sea level, provided that absolute workload is reduced in hypoxia so that relative exercise intensity is the same.

History

School

  • Sport, Exercise and Health Sciences

Published in

European Journal of Applied Physiology

Volume

116

Pages

1219 - 1229

Citation

SVENDSEN, I.S., HEM, E. and GLEESON, M., 2016. Effect of acute exercise and hypoxia on markers of systemic and mucosal immunity. European Journal of Applied Physiology, 116 (6), pp. 1219 - 1229

Publisher

Springer Verlag © The Author(s)

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/

Acceptance date

12/04/2016

Publication date

2016-04-29

Notes

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

ISSN

1439-6327

Language

en

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