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Effects of substituting sedentary time with physical activity on metabolic risk

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posted on 30.10.2015 by Mark Hamer, Emmanuel Stamatakis, Andrew Steptoe
Purpose: The detrimental effects of sedentary time on health may act by replacing time spent in physical activities. The aim of this study was to examine cross-sectional associations between objectively assessed sedentary and physical activity domains and cardiometabolic risk factors using a novel isotemporal substitution paradigm. Methods: Participants were 445 healthy men and women (mean age, 66 ± 6 yr), without history or objective signs of cardiovascular disease, drawn from the Whitehall II epidemiological cohort. Physical activity was objectively measured using accelerometers (ActiGraph GT3X) worn around the waist during waking hours for 4–7 consecutive days. We examined the effects of replacing sedentary time with light activity or moderate-to-vigorous physical activity (MVPA) on a range of risk factors (HDL cholesterol, triglycerides, HbA1c, and body mass index) using an isotemporal substitution paradigm. Results: In partition models, where the time in each of the intensity categories was held constant, only MVPA remained associated with risk factors. In isotemporal substitution models that held total (wear) time constant, replacing 10-min sedentary time with an equal amount of MVPA was associated with favorable effects in all risk factors, including HbA1c (B = −0.023; 95% confidence interval (CI), −0.043 to −0.002), BMI (B = −0.39; 95% CI, −0.54 to −0.24), HDL cholesterol (B = 0.037; 95% CI, 0.021–0.054), and triglycerides (B = −0.035; 95% CI, −0.061 to −0.009). Conclusions: The associations between sedentary behavior and cardiometabolic risk may be dependent on the types of activities that are displaced by sedentary time.

Funding

This study was funded by the British Heart Foundation (RE/10/ 005/28296).

History

School

  • Sport, Exercise and Health Sciences

Published in

Medicine and Science in Sports and Exercise

Citation

HAMER, M., STAMATAKIS, E. and STEPTOE, A., 2014. Effects of substituting sedentary time with physical activity on metabolic risk. Medicine and Science in Sports and Exercise, 46 (10), pp. 1946–1950.

Publisher

American College of Sports Medicine (ACSM)

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 Unported (CC BY-NC-ND 3.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc-nd/3.0/

Publication date

2014

Notes

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http:// creativecommons.org/licenses/by-nc-nd/3.0.

ISSN

1530-0315

Language

en

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