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EuroTracker (R) dyes: design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging

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posted on 15.09.2015 by Stephen Butler, Martina Delbianco, Laurent Lamarque, Brian K. McMahon, Emily R. Neil, Robert Pal, David Parker, James W. Walton, Jurriaan M. Zwier
The development of the brightest luminescent europium(III) complexes is traced, including analysis of the C3-symmetric core complex based on a functionalized triazacyclononane and identification of the most suitable strongly absorbing chromophore. Strategies for the synthesis of the complexes, including enantiopure analogues, are outlined and opportunities for applications in time-resolved microscopy and spectral imaging emphasised. Practicable examples are introduced, including selective organelle staining for cellular optical imaging at 65 nm resolution and the development of new bioassays using time resolved FRET methods.

Funding

This work was supported by the ERC (SJB, ERN, RP, DP; FCC 266804), EC and EPSRC.

History

School

  • Science

Department

  • Chemistry

Published in

DALTON TRANSACTIONS

Volume

44

Issue

11

Pages

4791 - 4803 (13)

Citation

BUTLER, S.J. ... et al, 2015. EuroTracker (R) dyes: design, synthesis, structure and photophysical properties of very bright europium complexes and their use in bioassays and cellular optical imaging. Dalton Transactions, 44 (11), pp. 4791 - 4803.

Publisher

© The Royal Society of Chemistry

Version

NA (Not Applicable or Unknown)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2015

Notes

This article was accepted for publication in the journal, Dalton Transactions [© Royal Society of Chemistry]. The definitive version is available at: http://dx.doi.org/10.1039/c4dt02785j

ISSN

1477-9226

Language

en

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