Exploiting nucleobase-containing materials: from monomers to complex morphologies using RAFT dispersion polymerization
journal contributionposted on 14.10.2016 by Yan Kang, Anais Pitto-Barry, Helen Willcock, Wen-Dong Quan, Nigel Kirby, Ana M. Sanchez, Rachel K. O'Reilly
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The synthesis of nucleobase-containing polymers was successfully performed by RAFT dispersion polymerization in both chloroform and 1,4-dioxane and self-assembly was induced by the polymerizations. A combination of scattering and microscopy techniques were used to characterize the morphologies. It is found that the morphologies of self-assembled nucleobase-containing polymers are solvent dependent. By varying the DP of the core-forming block, only spherical micelles with internal structures were obtained in chloroform when using only adenine-containing methacrylate or a mixture of adenine-containing methacrylate and thymine-containing methacrylate as monomers. However, higher order structures and morphology transitions were observed in 1,4-dioxane. A sphere-rod-lamella-twisted bilayer transition was observed in this study. Moreover, the kinetics of the dispersion polymerizations were studied in both solvents, suggesting a different formation mechanism in these systems.
The SECs used in this research were ... partly funded by the European Regional Development Fund (ERDF). Dr Ana M. Sanchez thanks the Science City Research Alliance and the HEFCE Strategic Development Fund for funding support.
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