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Femtomolar detection of silver nanoparticles by flow-enhanced direct-impact voltammetry at a microelectrode array

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posted on 12.02.2019 by Stanislav V. Sokolov, Thomas R. Bartlett, Peter Fair, Stephen Fletcher, Richard G. Compton
We report the femtomolar detection of silver (Ag) nanoparticles by direct-impact voltammetry. This is achieved through the use of a random array of microelectrodes (RAM) integrated into a purpose-built flow cell, allowing combined diffusion and convection to the electrode surface. A coupled RAM-flow cell system is implemented and is shown to give reproducible wall-jet type flow characteristics, using potassium ferrocyanide as a molecular redox species. The calibrated flow system is then used to detect and quantitatively size Ag nanoparticles at femtomolar concentrations. Under flow conditions, it is found the nanoparticle impact frequency increases linearly with the volumetric flow rate. The resulting limit of detection is more than 2 orders of magnitude smaller than the previous detection limit for direct-impact voltammetry (900 fM) [J. Ellison et al. Sens. Actuators, B 2014, 200, 47], and is more than 30 times smaller than the previous detection limit for mediated-impact voltammetry (83 fM) [T. M. Alligrant et al. Langmuir 2014, 30, 13462].

Funding

The authors of this work acknowledge funding from the European Research Council (ERC) under the European Union’s Seventh Framework Program (No. FP/2007-2013)/ERC Grant Agreement No. [320403].

History

School

  • Science

Department

  • Chemistry

Published in

Analytical Chemistry

Volume

88

Issue

17

Pages

8908 - 8912

Citation

SOKOLOV, S.V. ... et al, 2016. Femtomolar detection of silver nanoparticles by flow-enhanced direct-impact voltammetry at a microelectrode array. Analytical Chemistry, 88 (17), pp.8908-8912.

Publisher

© American Chemical Society

Version

VoR (Version of Record)

Acceptance date

05/08/2016

Publication date

2016-08-05

Notes

This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. Full details of this licence are available at: https://pubs.acs.org/page/policy/authorchoice_termsofuse.html

ISSN

0003-2700

eISSN

1520-6882

Language

en

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