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Fumarate-loaded electrospun nanofibers with anti-inflammatory activity for fast recovery of mild skin burns

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journal contribution
posted on 17.11.2016, 11:27 by Ilaria Romano, Maria Summa, Jose A. Heredia-Guerrero, R. Spano, Luca Ceseracciu, C. Pignatelli, Rosalia Bertorelli, Elisa Mele, Athanassia Athanassiou
In the biomedical sector the availability of engineered scaffolds and dressings that control and reduce inflammatory states is highly desired, particularly for the management of burn wounds. In this work, we demonstrate for the first time, to the best of our knowledge, that electrospun fibrous dressings of poly(octyl cyanoacrylate) (POCA) combined with polypropylene fumarate (PPF) possess anti-inflammatory activity and promote the fast and effective healing of mild skin burns in an animal model. The fibers produced had an average diameter of (0.8  ±  0.1) µm and they were able to provide a conformal coverage of the injured tissue. The application of the fibrous mats on the burned tissue effectively reduced around 80% of the levels of pro-inflammatory cytokines in the first 48 h in comparison with un-treated animals, and enhanced skin epithelialization. From histological analysis, the skin thickness of the animals treated with POCA : PPF dressings appeared similar to that of one of the naïve animals: (13.7  ±  1.4) µm and (14.3  ±  2.5) µm for naïve and treated animals, respectively. The density of dermal cells was comparable as well: (1100  ±  112) cells mm−2 and (1358  ±  255) cells mm−2 for naïve and treated mice, respectively. The results demonstrate the suitability of the electrospun dressings in accelerating and effectively promoting the burn healing process.

Funding

José A Heredia-Guerrero is supported by a Marie Curie In-tra-European Fellowship (BIOPROTO project), financed by the EU's Seventh Framework Programme for Research (FP7).

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Materials

Published in

Biomedical Materials

Volume

11

Issue

4

Pages

041001 - 041001

Citation

ROMANO, I. ... et al, 2016. Fumarate-loaded electrospun nanofibers with anti-inflammatory activity for fast recovery of mild skin burns. Biomedical Materials, 11 (4), pp. 041001-041001.

Publisher

© IOP Publishing

Version

AM (Accepted Manuscript)

Acceptance date

16/06/2016

Publication date

2016

Notes

This is an author-created, un-copyedited version of an article published in Biomedical Materials. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at http://dx.doi.org/10.1088/1748-6041/11/4/041001

ISSN

1748-6041

eISSN

1748-605X

Language

en

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