1-s2.0-S0021979713010692-main.pdf (2.27 MB)
0/0

Glass capillary microfluidics for production of monodispersed poly (dl-lactic acid) and polycaprolactone microparticles: experiments and numerical simulations

Download (2.27 MB)
journal contribution
posted on 09.12.2013 by Goran Vladisavljevic, Hamed Shahmohamadi, Diganta Das, Ekanem Ekanem, Zhandos Taunov, Lav Sharma
Hypothesis: Droplet size in microfluidic devices is affected by wettability of the microfluidic channels. Three-dimensional countercurrent flow focusing using assemblies of chemically inert glass capillaries is expected to minimize wetting of the channel walls by the organic solvent. Experiments: Monodispersed polycaprolactone and poly(lactic acid) particles with a diameter of 18-150 μm were produced by evaporation of solvent (dichloromethane or 1:2 mixture of chloroform and toluene) from oil-in-water or water-in-oil-in-water emulsions produced in three-dimensional flow focusing glass capillary devices. The drop generation behaviour was simulated numerically using the volume of fluid method. Findings: The numerical results showed good agreement with high-speed video recordings. Monodispersed droplets were produced in the dripping regime when the ratio of the continuous phase flow rate to dispersed phase flow rate was 5-20 and the Weber number of the dispersed phase was less than 0.01. The porosity of polycaprolactone particles increased from 8 to 62% when 30 wt% of the water phase was incorporated in the organic phase prior to emulsification. The inner water phase was loaded with 0.156 wt% lidocaine hydrochloride to achieve a sustained drug release. 26 % of lidocaine was released after 1 h and more than 93 % of the drug was released after 130 h.

Funding

The work was supported by the Engineering and Physical Sciences Research Council (EPSRC) of the United Kingdom (grant reference number: EP/HO29923/1)

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Citation

VLADISAVLJEVIC, G.T. ... et al, 2014. Glass capillary microfluidics for production of monodispersed poly (dl-lactic acid) and polycaprolactone microparticles: experiments and numerical simulations. Journal of Colloid and Interface Science, 418, pp. 163-170.

Publisher

Elsevier © the authors

Version

VoR (Version of Record)

Publisher statement

This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution 3.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/

Publication date

2014

Notes

This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution 3.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/3.0/

Language

en

Licence

Exports