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Hand grip strength and cognitive function among elderly cancer survivors

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posted on 05.06.2018 by Lin Yang, Ai Koyanagi, Lee Smith, Liang Hu, Graham A. Colditz, Adetunji T. Toriola, Guillermo F. Lopez Sanchez, Davy Vancampfort, Mark Hamer, Brendon Stubbs, Thomas Waldhor
Background We evaluated the associations of handgrip strength and cognitive function in cancer survivors ≥ 60 years old using data from the National Health and Nutrition Examination Survey (NHANES). Methods Data in two waves of NHANES (2011–2014) were aggregated. Handgrip strength in kilogram (kg) was defined as the maximum value achieved using either hand. Two cognitive function tests were conducted among adults 60 years and older. The Animal Fluency Test (AFT) examines categorical verbal fluency (a component of executive function), and the Digital Symbol Substitution test (DSST) assesses processing speed, sustained attention, and working memory. Survey analysis procedures were used to account for the complex sampling design of the NHANES. Multiple linear regression models were used to estimate associations of handgrip strength with cognitive test scores, adjusting for confounders (age, gender, race/ethnicity, education, marital status, smoking status, depressive symptoms and leisure time physical activity). Results Among 383 cancer survivors (58.5% women, mean age = 70.9 years, mean BMI = 29.3 kg/m2), prevalent cancer types were breast (22.9%), prostate (16.4%), colon (6.9%) and cervix (6.2%). In women, each increase in kg of handgrip strength was associated with 0.20 (95% CI: 0.08 to 0.33) higher score on AFT and 0.83 (95% CI: 0.30 to 1.35) higher score on DSST. In men, we observed an inverted U-shape association where cognitive function peaked at handgrip strength of 40–42 kg. Conclusions Handgrip strength, a modifiable factor, appears to be associated with aspects of cognitive functions in cancer survivors. Prospective studies are needed to address their causal relationship.

Funding

Ai Koyanagi's work is supported by the Miguel Servet contract financed by the CP13/00150 and PI15/00862 projects, integrated into the National R + D + I and funded by the Instituto de Salud Carlos III (ISCIII) - General Branch Evaluation and Promotion of Health Research - and the European Regional Development Fund (ERDF-FEDER).

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  • Sport, Exercise and Health Sciences

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PLoS ONE

Citation

YANG, L. ... et al, 2018. Hand grip strength and cognitive function among elderly cancer survivors. PLoS ONE, 13 (6), e0197909.

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Public Library of Science (PLoS) © Yang et al.

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VoR (Version of Record)

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This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/

Acceptance date

17/05/2018

Publication date

2018

Notes

This is an Open Access Article. It is published by Public Library of Science under the Creative Commons Attribution 4.0 International Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

ISSN

1932-6203

Language

en

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