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Hot water immersion induces an acute cytokine response in cervical spinal cord injury

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posted on 11.09.2015 by Christof Leicht, Ken Kouda, Yasunori Umemoto, M. Banno, Tokio Kinoshita, T. Moriki, T. Nakamura, Nicolette Bishop, Vicky Goosey-Tolfrey, Fumihiro Tajima
Purpose: The dysfunctional sympathetic nervous system in individuals with cervical spinal cord injury (CSCI) impairs adrenergic responses and may, therefore, contribute to the blunted post-exercise cytokine response. The purpose of this study was to investigate an alternative way to exercise to induce an acute cytokine response by passive core temperature elevation in CSCI. Methods: Seven male participants with a motor complete CSCI and 8 male able-bodied controls were immersed for 60 min in water set at a temperature 2 °C above the individuals’ resting oesophageal temperature. Blood was collected pre, post, and every hour up to 4 h post-immersion. Results: Hot water immersion resulted in an IL-6 plasma concentration mean increase of 133 ± 144 % in both groups (P = 0.001). On a group level, IL-6 plasma concentrations were 68 ± 38 % higher in CSCI (P = 0.06). In both groups, IL-8 increased by 14 ± 11 % (P = 0.02) and IL-1ra by 18 ± 17 % (P = 0.05). Catecholamine plasma concentrations were significantly reduced in CSCI (P < 0.05) and did not increase following immersion. Conclusions: Passive elevation of core temperature acutely elevates IL-6, IL-8 and IL-1ra in CSCI despite a blunted adrenergic response, which is in contrast to earlier exercise interventions in CSCI. The present study lays the foundation for future studies to explore water immersion as an alternative to exercise to induce an acute cytokine response in CSCI.

Funding

This study was supported by grants from the Joint Usage/Research Center of Sports for Persons with Impairments (Tokyo, Japan), and the Research Center of Sports Medicine and Balneology (Natchi-Katsuura, Japan).

History

School

  • Sport, Exercise and Health Sciences

Published in

European Journal of Applied Physiology

Citation

LEICHT, C.A. ...et al., 2015. Hot water immersion induces an acute cytokine response in cervical spinal cord injury. European Journal of Applied Physiology, 115(11), pp.2243-2252.

Publisher

© Springer Verlag

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2015

Notes

The final publication is available at Springer via http://dx.doi.org/10.1007/s00421-015-3206-9

ISSN

1439-6327

Language

en

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