Carroll and James. 2019. Hydration, Arginine Vasopressin, and Glucoregulatory Health in Humans. A Critical Perspective..pdf (917.16 kB)
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Hydration, arginine vasopressin, and glucoregulatory health in humans: A critical perspective

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journal contribution
posted on 06.08.2019 by Harriet A. Carroll, Lewis James
Glucoregulatory diseases, such as type 2 diabetes are currently a key public health priority. Public health messages have started to include the addition of water in their dietary guidelines. Such guidelines however are not based on causal evidence pertaining to the health effects of increased water intake, but rather more heavily based upon non-causal or mechanistic data. One line of thinking linking fluid intake and health is that hypohydration induces elevated blood concentrations of arginine vasopressin (AVP). Research in the 1970s and 1980s implicated AVP in glucoregulation, supported by observational evidence. This important area of research subsequently appeared to stop until the 21st century during which interest in hypertonic saline infusion studies, animal AVP receptor knockout models, dietary and genetic associations, and human interventions manipulating hydration status have resurged. This narrative review briefly describes and critically evaluates the usefulness of the current AVP-glucoregulatory research. We offer suggestions on how to test the independent glucoregulatory effects of body water changes compared to elevated circulating AVP concentrations, such as investigating hydration manipulations using 3,4-Methylenedioxymethamphetamine. Whilst much research is still needed before making firm conclusions, the current evidence suggests that although AVP may be partially implicated in glucoregulation, more ecologically valid models using human participants suggests this effect might be independent of the hydration status. The key implication of this hypothesis if confirmed in future research is that manipulating the hydration status to reduce circulating AVP concentrations may not be an effective method to improve glucoregulatory health.

Funding

Economic and Social Research Council, grant number ES/J50015X/1

History

School

  • Sport, Exercise and Health Sciences

Published in

Nutrients

Volume

11

Issue

6

Publisher

MDPI

Version

VoR (Version of Record)

Rights holder

© The authors

Acceptance date

23/05/2019

Publication date

2019-05-28

Copyright date

2019

eISSN

2072-6643

Language

en

Depositor

Dr Lewis James

Article number

1201

Licence

Exports