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Hydroxyethylstarch in cryopreservation - mechanisms, benefits and problems

journal contribution
posted on 04.03.2016 by Alexandra Stolzing, Yahaira Naaldijk, Viktoriya Fedorova, Sebastian Sethe
As the progress of regenerative medicine places ever greater attention on cryopreservation of (stem) cells, tried and tested cryopreservation solutions deserve a second look. This article discusses the use of hydroxyethyl starch (HES) as a cryoprotectant. Charting carefully the recorded uses of HES as a cryoprotectant, in parallel to its further clinical use, indicates that some HES subtypes are a useful supplement to dimethysulfoxide (DMSO) in cryopreservation. However, we suggest that the most common admixture ratio of HES and DMSO in cryoprotectant solutions has been established by historical happenstance and requires further investigation and optimization. © 2012 Elsevier Ltd.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Transfusion and Apheresis Science

Volume

46

Issue

2

Pages

137 - 147

Citation

STOLZING, A. ...et al., 2012. Hydroxyethylstarch in cryopreservation - mechanisms, benefits and problems. Transfusion and Apheresis Science, 46(2), pp. 137-147.

Publisher

© Elsevier

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2012

Notes

This paper is in closed access.

ISSN

1473-0502

eISSN

1878-1683

Language

en

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