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Inflammation-mediating cytokine response to acute hand cycling exercise with/without functional electrical stimulation-evoked lower-limb cycling

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posted on 03.10.2016 by Tom Paulson, Nicolette Bishop, Brett Smith, Vicky Goosey-Tolfrey
This feasibility study compared the plasma inflammation-mediating cytokine response to an acute bout of handcycling (HC) with and without the addition of functional electrical stimulation (FES)-evoked lower-limb cycling. On two separate occasions, five recreationally active, community-based participants with motor complete paraplegia (thoracic 5-7) performed 30 min HC and hybrid exercise (HYB) at a fixed power output. Venous blood samples were collected at rest, immediately postexercise, 1 h postexercise (post+1) and 2 h postexercise (post+2). Plasma interleukin (IL)-6, IL-10, IL-1 receptor antagonist (IL-1ra), adrenaline, and cortisol concentrations were determined via enzyme-linked immunoassay. Plasma IL-6 concentrations were significantly (p < 0.04) elevated (~2.5-fold) at post+1 and post+2 in HYB only. A small (0.5-fold), nonsignificant (p > 0.05) increase in IL-6 was observed at post+1 in HC, with concentrations significantly higher in HYB at post+2 (p < 0.02). Plasma IL-1ra was unaffected in both trials. Although not reaching statistical significance (p = 0.15), a ~1-fold increase in IL-10 concentration was seen in HYB at post+2. In contrast, increases in adrenaline (p < 0.04) and cortisol (p = 0.08) were observed immediately postexercise in HC and HYB. Initial findings suggest paralyzed skeletal muscle releases IL-6 in response to FES-evoked contractions. HYB may provide a greater anti-inflammatory potential in individuals with a thoracic spinal cord injury compared with HC alone.

Funding

This material is based on work supported by resources from the Peter Harrison Centre for Disability Sport at Loughborough University, a grant from The Coca-Cola Foundation to support consumable costs, and sponsorship from the Standing Start charitable foundation to cover travel costs.

History

School

  • Sport, Exercise and Health Sciences

Published in

Journal of Rehabilitation Research and Development

Volume

51

Issue

4

Pages

645 - 654

Citation

PAULSON, T. ... et al., 2014. Inflammation-mediating cytokine response to acute hand cycling exercise with/without functional electrical stimulation-evoked lower-limb cycling. Journal of Rehabilitation Research and Development, 51 (4), pp.645-654.

Publisher

United States Department of Veterans Affairs

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2014

ISSN

0748-7711

eISSN

1938-1352

Language

en

Exports