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Influence of Niobium Pentoxide particulates on the properties of Brushite/Gelatin/Alginate membranes

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journal contribution
posted on 27.11.2018 by Hanan H. Beherei, Abdallah A. Shaltout, Mostafa Mabrouk, Nayera A.M. Abdelwahed, Diganta Das
Novel non-porous membranes were prepared by impregnating of nano-brushite and niobium pentoxide (Nb2O5) into a gelatin/alginate matrix. The physicochemical properties, morphology and mechanical properties of the prepared membranes were characterized using XRD, FTIR, SEM, TEM and universal testing machine, respectively. Swelling ability of the prepared membranes was determined in distilled water. The surfaces of the membranes were characterized by means of FTIR and SEM coupled with EDX after submersion in simulated body fluid (SBF) up to 15 days. Moreover, the calcium and phosphorus ion concentrations in the SBF were measured by UV-spectrophotometer. The in vitro drug release and the release mechanism of a model antibiotic, namely, ciprofloxacin (CFX), were tested in phosphate buffer saline (PBS) for 15 days. The antibacterial activities of the CFX-loaded membranes were tested against known microorganisms. The physicochemical properties, morphology, mechanical properties and swelling ability of the prepared membranes were found to be dependent on the presence of Nb2O5 allowing control of their properties. For example, the Nb2O5-loaded membranes exhibited a higher in vitro bioactivity and slower drug release compared to those of Nb2O5-free membranes. The CFX-loaded membranes also exhibited an excellent inhibition zones against the selected microorganisms. Overall, the prepared membranes have been found to be very promising for use in bone substitute’s applications.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Journal of Pharmaceutical Sciences

Volume

107

Issue

5

Pages

1361 - 1371

Citation

BEHEREI, H.H. ... et al., 2018. Influence of Niobium Pentoxide particulates on the properties of Brushite/Gelatin/Alginate membranes. Journal of Pharmaceutical Sciences, 107(5), pp. 1361-1371.

Publisher

Elsevier

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

17/01/2018

Publication date

2018

Notes

This paper was accepted for publication in the journal Journal of Pharmaceutical Sciences and the definitive published version is available at https://doi.org/10.1016/j.xphs.2018.01.014

ISSN

0022-3549

Language

en

Exports