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Isolation of novel para-pentyl phenyl benzoate from Mondia whitei. (Hook.F) Skeels (Periplocaceae), its structure, synthesis, and neuropharamacological evaluation

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posted on 02.02.2017 by Bamigboye J. Taiwo, Josephine Y. Osasan, Olujide O. Olubiyi, Idris A. Oyemitan, Shakir A. Atoyebi, Mark Elsegood, Raymond C.F. Jones
Background: Mondia whitei L. (Hook. F.) Skeels (Periplocaceae) is a medicinal plant used locally in managing pain, fever, loss of appetite and as aphrodiasc in the South-Western states of Nigeria. However, the fruit is consumed habitually in the South-Eastern states of Nigeria, leading to speculation that it may possess some central nervous system effect but which has not been scientifically investigated, hence this study. Methodology: Fresh fruits of Mondia whitei were collected and identified by a taxonomist. They were chopped into small pieces and extracted with absolute ethanol. The crude extract was subjected to various chromatographic techniques to isolate a novel compound whose structure was elucidated from the analysis of the crystal data and by extensive use of spectroscopy. The structure was confirmed by synthesis. The compound was subjected to anxiolytic and sedative activity assay. Computational analysis of the receptor binding event of isolated compound at the gamma amino butyric acid A receptor was also evaluated. Results: The structure of the compound was elucidated as para pentyl phenyl benzoate. The neuropharmacological evaluation of the compound indicated significant (p<0.05) depression of the central nervous system. The binding characteristics of the compound to gamma amino butyric acid A receptors appears to be more favorable than those obtained for gamma amino butyric acid, chlorpromazine, benzamidine, and is comparable with the affinity obtained for pentobarbitone and diazepam. Conclusion These present data provide evidence for the role of para pentyl phenyl benzoate in the habitual consumption of the fruit as well as its central nervous system activities.

Funding

We wish to thank the Commonwealth Scholarship Commission (CSC), United Kingdom for a fellowship award (NGCF-2012-160) to TBJ. We also wish to acknowledge the use of the EPSRC's Chemical Database Service hosted by the RSC.

History

School

  • Science

Department

  • Chemistry

Published in

African Journal of Traditional, Complementary and Alternative Medicines

Volume

14

Issue

1

Pages

219 - 230 (12)

Citation

TAIWO, B.J. ... et al, 2017. Isolation of novel para-pentyl phenyl benzoate from Mondia whitei. (Hook.F) Skeels (Periplocaceae), its structure, synthesis, and neuropharamacological evaluation. African Journal of Traditional, Complementary and Alternative Medicines, 14 (1), pp. 219-230.

Publisher

African Traditional Herbal Medicine Supporters Initiative (ATHMSI)

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/

Acceptance date

15/11/2016

Publication date

2016-11-23

Notes

This is an Open Access article. It is published under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

ISSN

0189-6016

eISSN

2505-0044

Language

en

Licence

Exports