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Lidocaine-loaded fish scale-nanocellulose biopolymer composite microneedles

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posted on 07.04.2017 by Pangkhi Medhi, Ololade Olatunji, Atul Nayak, Chandrateja Uppuluri, Richard T. Olsson, Buchi N. Nalluri, Diganta Das
Microneedle (MN) technology has emerged as an effective drug delivery system, and it has tremendous potential as a patient friendly substitute for conventional methods for transdermal drug delivery (TDD). In this paper, we report on the preparation of lidocaine-loaded biodegradable microneedles, which are manufactured from fish scale-derived collagen. Lidocaine, a common tissue numbing anaesthetic, is loaded in these microneedles with an aim of delivering the drug with controlled skin permeation. Evaluation of lidocaine permeation in porcine skin has been successfully performed using Franz diffusion cell (FDC) which has shown that the drug permeation rate increases from 2.5 to 7.5% w/w after 36 h and pseudo steady state profile is observed from 5.0 to 10.0% w/w lidocaine-loaded microneedle. Swelling experiments have suggested that the microneedles have negligible swellability which implies that the patch would stick to the tissue when inserted. The experiments on MN dissolution have depicted that the lidocaine loaded in the patch is lower than the theoretical loading, which is expected as there can be losses of the drug during initial process manufacture.

Funding

The authors wish to acknowledge the British Council, UK, and Directorate of Science and Technology (DST), India, for supporting the work. This research is supported by the International Foundation for Science IFS (Grant No. F/5544-1).

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

AAPS PharmSciTech

Volume

18

Issue

5

Pages

1488-1494

Citation

MEDHI, P. ... et al, 2017. Lidocaine-loaded fish scale-nanocellulose biopolymer composite microneedles. AAPS PharmSciTech, 18(5), pp. 1488-1494

Publisher

Springer © American Association of Pharmaceutical Scientists

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

06/03/2017

Publication date

2017-03-28

Copyright date

2017

Notes

This is a post-peer-review, pre-copyedit version of an article published in AAPS PharmSciTech. The final authenticated version is available online at: http://dx.doi.org/10.1208/s12249-017-0758-5.

eISSN

1530-9932

Language

en

Exports