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Lowering of blood pressure after nitrate-rich vegetable consumption is abolished with the co-ingestion of thiocyanate-rich vegetables in healthy normotensive males

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posted on 19.01.2018 by Rebecca Dewhurst-Trigg, Toby Yeates, Jamie R. Blackwell, Christopher Thompson, Adam Linoby, Paul T. Morgan, Ida Clarke, Luke J. Connolly, Lee J. Wylie, Paul G. Winyard, Andrew M. Jones, Stephen Bailey
A diet rich in vegetables is known to provide cardioprotection. However, it is unclear how the consumption of different vegetables might interact to influence vascular health. This study tested the hypothesis that nitrate-rich vegetable consumption would lower systolic blood pressure but that this effect would be abolished when nitrate-rich and thiocyanate-rich vegetables are co-ingested. On four separate occasions, and in a randomised cross-over design, eleven healthy males reported to the laboratory and consumed a 750 mL vegetable smoothie that was either: low in nitrate (~ 0.3 mmol) and thiocyanate (~ 5 μmol), low in nitrate and high in SCN- (~ 72 μmol), high in nitrate (~ 4 mmol) and low in SCN- and high in nitrate and SCN-. Blood pressure as well as plasma and salivary [thiocyanate], [nitrate] and [nitrite] were assessed before and 3 hours after smoothie consumption. Plasma [nitrate] and [nitrite] and salivary [nitrate] were not different after consuming the two high-nitrate smoothies, but salivary [nitrite] was higher after consuming the high-nitrate low-thiocyanate smoothie (1183 ± 625 µM) compared to the high-nitrate high-thiocyanate smoothie (941 ± 532 µM; P<0.001). Systolic blood pressure was only lowered after consuming the high-nitrate low-thiocyanate smoothie (-3 ± 5 mmHg; P<0.05). The acute consumption of vegetables high in nitrate and low in thiocyanate lowered systolic blood pressure. However, when the same dose of nitrate-rich vegetables was co-ingested with thiocyanate-rich vegetables the increase in salivary [nitrite] was smaller and systolic blood pressure was not lowered. These findings might have implications for optimising dietary guidelines aimed at improving cardiovascular health.

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School

  • Sport, Exercise and Health Sciences

Published in

Nitric Oxide: Biology and Chemistry

Citation

DEWHURST-TRIGG, R. ... et al, 2018. Lowering of blood pressure after nitrate-rich vegetable consumption is abolished with the co-ingestion of thiocyanate-rich vegetables in healthy normotensive males. Nitric Oxide, 74, pp.39-46.

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© Elsevier

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

18/01/2018

Publication date

2018-02-19

Notes

This paper was accepted for publication in the journal Nitric Oxide and the definitive published version is available at https://doi.org/10.1016/j.niox.2018.01.009

ISSN

1089-8603

Language

en

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