Welch_et_al-2019-Campbell_Systematic_Reviews.pdf (7.28 MB)

Mass deworming for improving health and cognition of children in endemic helminth areas: A systematic review and individual participant data network meta‐analysis

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journal contribution
posted on 28.11.2019 by Vivian A Welch, Elizabeth Ghogomu, Alomgir Hossain, Alison Riddle, Michelle Gaffey, Paul Arora, Omar Dewidar, Rehana Salaam, Simon Cousens, Robert Black, T Déirdre Hollingsworth, Sue Horton, Peter Tugwell, Donald Bundy, Mary Christine Castro, Alison Eliott, Henrik Friis, Huong T Le, Chengfang Liu, Emily Rousham, Fabian Rohner, Charles King, Erliyani Sartono, Taniawati Supali, Peter Steinmann, Emily Webb, Franck Wieringa, Pattanee Winnichagoon, Maria Yazdanbakhsh, Zulfiqar A Bhutta, George Wells
Background
Soil transmitted (or intestinal) helminths and schistosomes affect millions of children worldwide.

Objectives
To use individual participant data network meta‐analysis (NMA) to explore the effects of different types and frequency of deworming drugs on anaemia, cognition and growth across potential effect modifiers.

Search Methods
We developed a search strategy with an information scientist to search MEDLINE, CINAHL, LILACS, Embase, the Cochrane Library, Econlit, Internet Documents in Economics Access Service (IDEAS), Public Affairs Information Service (PAIS), Social Services Abstracts, Global Health CABI and CAB Abstracts up to March 27, 2018. We also searched grey literature, websites, contacted authors and screened references of relevant systematic reviews.

Selection Criteria
We included randomised and quasirandomised deworming trials in children for deworming compared to placebo or other interventions with data on baseline infection.

Data Collection and Analysis
We conducted NMA with individual participant data (IPD), using a frequentist approach for random‐effects NMA. The covariates were: age, sex, weight, height, haemoglobin and infection intensity. The effect estimate chosen was the mean difference for the continuous outcome of interest.

Results
We received data from 19 randomized controlled trials with 31,945 participants. Overall risk of bias was low. There were no statistically significant subgroup effects across any of the potential effect modifiers. However, analyses showed that there may be greater effects on weight for moderate to heavily infected children (very low certainty evidence).

Authors' Conclusions
This analysis reinforces the case against mass deworming at a population‐level, finding little effect on nutritional status or cognition. However, children with heavier intensity infections may benefit more. We urge the global community to adopt calls to make data available in open repositories to facilitate IPD analyses such as this, which aim to assess effects for the most vulnerable individuals.
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Funding

Bill and Melinda Gates Foundation (funding reference number: OPP1140742)

History

School

  • Sport, Exercise and Health Sciences

Published in

Campbell Systematic Reviews

Volume

15

Issue

4

Publisher

John Wiley & Sons Ltd on behalf of The Campbell Collaboration

Version

VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Publication date

2019-11-20

Copyright date

2019

eISSN

1891-1803

Language

en

Depositor

Dr Emily Rousham. Deposit date: 27 November 2019

Article number

e1058

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