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Mechanical and chemical characterisation of bioresorbable polymeric stent over two-year in vitro degradation

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journal contribution
posted on 13.03.2019 by Raasti Naseem, Liguo Zhao, Vadim Silberschmidt, Yang Liu, O.W. Scaife, Helen Willcock, S.K. Eswaran, S. Hossainy
Polymeric stent is a temporary cardiovascular scaffold, made of biodegradable poly (l-lactic) acid, to treat coronary artery stenosis, with expected resorption by the human body over two to three years. In this paper, the mechanical properties of a polymeric stent over two-year in vitro degradation were studied and characterised using atomic force microscopy and nanoindentation techniques, complemented with analyses of weight loss, gel permeation chromatography and differential scanning calorimetry. Atomic force microscopy assessed stent degradation at the surface, whilst nanoindentation was able to investigate the property at a greater depth into the material. No significant changes to the Young’s modulus were observed with the atomic force microscopy due to bulk degradation nature of the polymer. Chemical analyses demonstrated a reduction of molecular weight and an increase of crystallinity, indicating degradation of the stents. Berkovich nanoindentation showed a trend of reduction in modulus over in vitro degradation, which was, however, not continuous due to the variations of measurements associated with the pyramidal indenter tip and the semi-crystalline structure of the polymer.

Funding

This work is funded by the British Heart Foundation PhD research project (Grant number: FS/15/21/31424; Title: Towards controlling the mechanical performance of polymeric bioresorbable vascular stent during biodegradation).

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Journal of Biomaterials Applications

Citation

NASEEM, R. ... et al, 2019. Mechanical and chemical characterisation of bioresorbable polymeric stent over two-year in vitro degradation. Journal of Biomaterials Applications, 34 (1), pp.61-73.

Publisher

SAGE Publications © The Authors

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

04/03/2019

Publication date

2019-04-05

Notes

This paper was accepted for publication in the journal Journal of Biomaterials Applications and the definitive published version is available at https://doi.org/10.1177/0885328219839591.

ISSN

0885-3282

eISSN

1530-8022

Language

en

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