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Mesenchymal stem cell-derived extracellular vesicles may promote breast cancer cell dormancy

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posted on 17.01.2019 by Jake Casson, Owen Davies, Carol-Anne Smith, Matthew J. Dalby, Catherine C. Berry
Disseminated breast cancer cells have the capacity to metastasise to the bone marrow and reside in a dormant state within the mesenchymal stem cell (MSC) niche. Research has focussed on paracrine signalling factors, such as soluble proteins, within the microenvironment. However, it is now clear extracellular vesicles (EVs) secreted by resident MSCs into this microenvironment also play a key role in the initiation of dormancy. Dormancy encourages reduced cell proliferation and migration, whilst upregulating cell adhesion, thus retaining the cancer cells within the bone marrow microenvironment. Here, MCF7 breast cancer cells were treated with MSC-derived EVs, resulting in reduced migration in 2D and 3D culture, with reduced cell proliferation and enhanced adhesion, collectively supporting cancer cell dormancy.

Funding

The authors would like to reference funding from the BBSRC for this work, grant reference number BB/L008661/1.

History

School

  • Sport, Exercise and Health Sciences

Published in

Journal of Tissue Engineering

Volume

9

Pages

204173141881009 - 204173141881009

Citation

CASSON, J. ... et al., 2018. Mesenchymal stem cell-derived extracellular vesicles may promote breast cancer cell dormancy. Journal of Tissue Engineering, 9, pp. 1-7.

Publisher

© The Authors. Published by SAGE Publications

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/

Acceptance date

10/10/2018

Publication date

2018

Notes

This is an Open Access Article. It is published by Sage under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

ISSN

2041-7314

eISSN

2041-7314

Language

en

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