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Microfluidic hydrodynamic focusing based synthesis of POPC liposomes for model biological systems

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posted on 25.05.2017 by M. Mijajlovic, D. Wright, Vladimir Zivkovic, J.X. Bi, Mark Biggs
Lipid vesicles have received significant attention in areas ranging from pharmaceutical and biomedical engineering to novel materials and nanotechnology. Microfluidic-based synthesis of liposomes offers a number of advantages over the more traditional synthesis methods such as extrusion and sonication. One such microfluidic approach is microfluidic hydrodynamic focusing (MHF), which has been used to synthesize nanoparticles and vesicles of various lipids. We show here that this method can be utilized in synthesis of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) vesicles with controllable size. Since POPC is among the primary constituents of cellular membranes, this work is of direct applicability to modelling of biological systems and development of nano-containers with higher biologic compatibility for pharmaceutical and medical applications. © 2012 Elsevier B.V.

History

School

  • Science

Department

  • Chemistry

Published in

Colloids and Surfaces B: Biointerfaces

Volume

104

Pages

276 - 281

Citation

MIJAJLOVIC, M., 2013. Microfluidic hydrodynamic focusing based synthesis of POPC liposomes for model biological systems. Colloids and Surfaces B: Biointerfaces, 104, pp. 276-281.

Publisher

© Elsevier

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2013

Notes

This paper was accepted for publication in the journal Colloids and Surfaces B: Biointerfaces and the definitive published version is available at http://dx.doi.org/10.1016/j.colsurfb.2012.12.020

ISSN

0927-7765

eISSN

1873-4367

Language

en

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