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Modelling and control of combined cooling and antisolvent crystallization processes

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journal contribution
posted on 14.07.2009 by Zoltan Nagy, M. Fujiwara, Richard D. Braatz
Although for decades nearly all pharmaceuticals have been purified by crystallization, there have been a disproportionate number of problems associated with the operation and control of these processes. This paper provides an overview of the recent advances in model-based and model-free (direct design) approaches to control the crystallization of pharmaceuticals, treating both antisolvent and cooling crystallization. A model-based combined technique which simultaneously controls the antisolvent addition rate and the cooling profile is presented. A population balance model of the combined cooling-antisolvent addition system is developed and a moments model is used in optimal control strategies with various objective functions. The simulation and experimental results show the advantages of the combined approach.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Citation

NAGY, Z.K., FUJIWARA, M. and BRAATZ, R.D., 2008. Modelling and control of combined cooling and antisolvent crystallization processes. Journal of Process Control, 18 (9), pp. 856-864.

Publisher

© Elsevier

Version

AM (Accepted Manuscript)

Publication date

2008

Notes

This article was published in the Journal of Process Control [© Elsevier]. The definitive version is available at: www.elsevier.com/locate/jprocont

ISSN

0959-1524

Language

en

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