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N-3 fatty acids and asthma

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journal contribution
posted on 03.07.2017 by Aishwarya Kumar, Sarabjit Mastana, Martin Lindley
Copyright © 2016 The Authors. Asthma is one of the most common and prevalent problems worldwide affecting over 300 million individuals. There is some evidence from observational and intervention studies to suggest a beneficial effect of n-3 PUFA in inflammatory diseases, specifically asthma. Marine-based n-3 PUFA have therefore been proposed as a possible complementary/alternative therapy for asthma. The proposed anti-inflammatory effects of n-3 fatty acids may be linked to a change in cell membrane composition. This altered membrane composition following n-3 fatty acid supplementation (primarily EPA and DHA) can modify lipid mediator generation via the production of eicosanoids with a reduced inflammatory potential/impact. A recently identified group of lipid mediators derived from EPA including E-series resolvins are proposed to be important in the resolution of inflammation. Reduced inflammation attenuates the severity of asthma including symptoms (dyspnoea) and exerts a bronchodilatory effect. There have been no major health side effects reported with the dietary supplementation of n-3 fatty acids or their mediators; consequently supplementing with n-3 fatty acids is an attractive non-pharmacological intervention which may benefit asthma.

History

School

  • Sport, Exercise and Health Sciences

Published in

Nutrition Research Reviews

Volume

29

Issue

1

Pages

1 - 16

Citation

KUMAR, A., MASTANA, S.S. and LINDLEY, M.R., 2016. N-3 Fatty acids and asthma. Nutrition Research Reviews, 29(1), pp. 1-16.

Publisher

© The Authors. Published by Cambridge University Press.

Version

VoR (Version of Record)

Publication date

2016-01-26

Notes

This article has been published in a revised form in Nutrition Research Reviews http://dx.doi.org/10.1017/S0954422415000116. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © copyright holder.

ISSN

0954-4224

eISSN

1475-2700

Language

en

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