Spartano NL 2019 - Actical and gait (accepted).pdf (927.35 kB)

Objective physical activity and physical performance in middle-aged and older adults

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journal contribution
posted on 24.04.2019 by Nicole L. Spartano, Asya Lyass, Martin G. Larson, Tuyen Tran, Charlotte Andersson, Susan J. Blease, Dale Esliger, Ramachandran S. Vasan, Joanne M. Murabito
Background: Older adults may have difficulty meeting the Physical Activity (PA) Guidelines. A favorable balance between PA and sedentary time (SED) is an important determinant of physical performance in older adults. Our objective was to explore associations of PA/SED with physical performance across mid-older age in adults without overt mobility disability. Methods: Framingham Offspring Study participants free of mobility disability with accelerometry and physical performance data (gait speed, chair stand time, and handgrip strength), were studied in cross-sectional analysis (n = 1352). We regressed physical performance on PA level, measured using steps, moderate to vigorous (MV)PA and SED. We stratified by age groups, adjusted for covariates, and modelled MVPA and SED separately and together as predictors. Results: Only 38% of adults 50–64 years and 15% of adults ≥75 years met the PA Guidelines (i.e., 150 min MVPA per week). Individuals achieving at least 5 min/day of MVPA had 0.062 ± 0.013 m/s greater gait speed and better chair stands and handgrip strength (in women) than those with <5 min/day of MVPA (p < 0.01) across mid-older age. SED was associated with poorer performance on gait speed and chair stand tests, but results were not significant after adjusting for MVPA (p > 0.05). For adults ≥75 years, every 5000 more steps/day related to ~0.045 m/s greater gait speed (p = 0.006). Conclusion: Our cross-sectional study demonstrated that, across mid-older adulthood, MVPA related to better physical performance, but in adults ≥75 years, total steps walked associated with better gait speed. These data warrant future research on the impact of PA on physical performance and health outcomes in older age.


The work was supported by funding from the National Institutes of Health (NIH) (N01-HC25195, HHSN268201500001I; R01-AG047645; R01-HL131029; R56-AG029451); and American Heart Association(15GPSGC24800006 and 16MCPRP30310001). Dr. Vasan is supported in part by the Evans Medical foundation and the Jay and Louis Coffman Endowment, Department of Medicine, BUSM.



  • Sport, Exercise and Health Sciences

Published in

Experimental Gerontology




203 - 211


SPARTANO, N.L. ... et al, 2019. Objective physical activity and physical performance in middle-aged and older adults. Experimental Gerontology, 119, pp.203-211.


© Elsevier


AM (Accepted Manuscript)

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This paper was accepted for publication in the journal Experimental Gerontology and the definitive published version is available at

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