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Patient-specific computational hemodynamics of intracranial aneurysms from 3D rotational angiography and CT angiography: An in vivo reproducibility study

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journal contribution
posted on 31.10.2019, 10:14 by AJ Geers, I Larrabide, AG Radaelli, H Bogunovic, Minsuok Kim, HAF Gratama van Andel, CB Majoie, E VanBavel, AF Frangi
BACKGROUND AND PURPOSE: Patient-specific simulations of the hemodynamics in intracranial aneurysms can be constructed by using image-based vascular models and CFD techniques. This work evaluates the impact of the choice of imaging technique on these simulations. MATERIALS AND METHODS: Ten aneurysms, imaged with 3DRA and CTA, were analyzed to assess the reproducibility of geometric and hemodynamic variables across the 2 modalities. RESULTS: Compared with 3DRA models, we found that CTA models often had larger aneurysm necks (P=.05) and that most of the smallest vessels (between 0.7 and 1.0 mm in diameter) could not be reconstructed successfully with CTA. With respect to the values measured in the 3DRA models, the flow rate differed by 14.1 ± 2.8% (mean ± SE) just proximal to the aneurysm and 33.9 ± 7.6% at the aneurysm neck. The mean WSS on the aneurysm differed by 44.2 ± 6.0%. Even when normalized to the parent vessel WSS, a difference of 31.4 ± 9.9% remained, with the normalized WSS in most cases being larger in the CTA model (P =.04). Despite these substantial differences, excellent agreement (k ≥ 0.9) was found for qualitative variables that describe the flow field, such as the structure of the flow pattern and the flow complexity. CONCLUSIONS: Although relatively large differences were found for all evaluated quantitative hemodynamic variables, the main flow characteristics were reproduced across imaging modalities.

Funding

@neurIST Integrated Project (cofinanced by the European Commission through contract no. IST-027703)

Spanish Ministry of Science and Innovation

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

American Journal of Neuroradiology

Volume

32

Issue

3

Pages

581 - 586

Publisher

American Society of Neuroradiology (ASNR)

Version

VoR (Version of Record)

Rights holder

© American Journal of Neuroradiology

Publisher statement

This is an Open Access Article. It is published by ASNR under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

20/07/2010

Publication date

2011-03

Copyright date

2011

ISSN

0195-6108

eISSN

1936-959X

Language

en

Depositor

Dr Minsuok Kim Deposit date: 28 October 2019

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