Johnson_s12916-018-1059-x.pdf (1.11 MB)

Patterns of adiposity, vascular phenotypes and cognitive function in the 1946 British Birth Cohort

Download (1.11 MB)
journal contribution
posted on 15.05.2018 by Stefano Masi, Georgios Georgiopoulos, Tauseef Khan, Will Johnson, Andrew Wong, Marietta Charakida, P. Whincup, Alun D. Hughes, Marcus Richards, Rebecca Hardy, John Deanfield
Objectives: The relationship between long term exposure to whole body or central obesity and cognitive function as well as its potential determinants remain controversial. We assessed the association of different patterns of whole body and central adiposity exposure with cognitive function at 60-64 years, and the influence of vascular phenotypes on this association. Research Design and Methods: Data from 1249 participants of the prospective cohort MRC National Survey of Health and Development with adiposity (BMI and waist circumference, WC), vascular (carotid intima-media thickness and carotid-femoral pulse wave velocity) and cognitive function (memory, processing speed, reaction time) data at 60–64 were used to assess the associations between different patterns of adult WC or BMI exposure (from 36 years of age) and late midlife cognitive performance, as well as the proportion of this association explained by cardiovascular phenotypes. Results: Longer exposure to elevated WC was related with lower memory (p<0.001 for both) and longer choice reaction time (p=0.003). A faster gain of WC between 36-43 years were associated with the largest change in reaction time and memory test (P<0.05 for all). Similar associations with cognitive tests were observed when patterns of WC were substituted with patterns of BMI, but when WC and BMI were included in the same model, only patterns of WC remained significantly associated with cognitive function. Adjustment for vascular phenotypes, levels of cardiovascular risk factors, physical activity, education, childhood cognition and socio-economic position did not affect these associations. DISCUSSION: Longer exposure to elevated WC or BMI and faster WC or BMI gains between 36-43 years are related to lower cognitive functions at 60-64 years. Patterns of WC in adulthood could provide additional information in predicting late midlife cognitive functions than patterns of BMI. The acquisition of an adverse cardiovascular phenotype associated with adiposity is unlikely to account for these relationships.

Funding

The UK Medical Research Council provides core funding for the MRC National Survey of Health and Development and supports RH and MR (grant numbers MC_UU_12019/1, MC_UU_12019/2 and MC_UU_12019/3). WJ acknowledges support from the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre, which is a partnership between University Hospitals of Leicester NHS Trust, Loughborough University and the University of Leicester. JD and SM are supported by the British Heart Foundation.

History

School

  • Sport, Exercise and Health Sciences

Published in

BMC Medicine

Citation

MASI, S. ...et al., 2018. Patterns of adiposity, vascular phenotypes and cognitive function in the 1946 British Birth Cohort. BMC Medicine, 16:75.

Publisher

BioMed Central

Version

NA (Not Applicable or Unknown)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/

Acceptance date

26/04/2018

Publication date

2018-05-28

Notes

This is an Open Access Article. It is published by BioMed Central under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

ISSN

1741-7015

Language

en

Licence

Exports

Logo branding

Licence

Exports