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Phytoestrogens and cognitive function: A review

journal contribution
posted on 29.06.2017, 14:36 by Mira Soni, T.B. Rahardjo, Rodiyah Soekardi, Yenny Sulistyowati, Lestariningsih, Amina Yesufu-Udechuku, Atik Irsan, Eef Hogervorst
Neuroprotective effects of phytoestrogen compounds (found in soy) have been demonstrated in animal research and cell culture studies. In particular, phytoestrogens have been shown to reduce Alzheimer's Disease (AD) related pathology, potentially alleviating risk of AD progression. In addition to their antioxidant properties, soy products also have the ability to affect cognition via interaction with estrogen receptors. However, observational studies and randomised controlled trials in humans have resulted in inconclusive findings within this domain. There are several possible reasons for these discrepant data. Studies which report no effect of phytoestrogens on cognition have mainly been carried out in European cohorts, with an average low dietary consumption. In contrast, investigation of Asian populations, with a higher general intake of tofu (a non-fermented soy product) have shown negative associations with cognitive function in those over the age of 65. Consideration of type of soy product is important, as in the latter sample, protective effects of tempe (fermented soy) were also observed. Limited data provide evidence that effects of phytoestrogens on cognition may be modified by dosage, duration of consumption and cognitive test used. Additionally, characteristics of the study population including age, gender, ethnicity and menopausal status appear to be mediating variables. Phytoestrogen treatment interventions have also shown time-limited positive effects on cognition. These findings are consistent with estrogen treatment studies, where initial positive short-term cognitive effects may occur, which reverse with long-term continuous use in elderly women. Well controlled, large scale studies are needed to assess the effects of phytoestrogens on the aging brain and provide further understanding of this association. © 2013 Elsevier Ireland Ltd. All rights reserved.

Funding

We would like to acknowledge the Alzheimer’s Research Trust which funded the Aging in Indonesia study (ART/PPG2006A/2)

History

School

  • Sport, Exercise and Health Sciences

Published in

Maturitas

Volume

77

Issue

3

Pages

209 - 220

Citation

SONI, M. ...et al., 2014. Phytoestrogens and cognitive function: A review. Maturitas, 77(3), pp. 209-220.

Publisher

© Elsevier

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2014

Notes

This paper is in closed access.

ISSN

0378-5122

eISSN

1873-4111

Language

en

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