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Premature ovarian insufficiency and neurological function

journal contribution
posted on 29.06.2017 by Mira Soni, Eef Hogervorst
Premature ovarian insufficiency (POI) involves loss of ovarian function before age 40. POI has been associated with neurological dysfunction and an increased risk of dementia, perhaps due to depletion in estrogen levels. The present review discusses the effects of POI caused by genetic disorder, natural premature menopause, surgical menopause, breast cancer treatment and gonadotropin-re-leasing hormone (GnRH) agonist treatment. Overall, data suggest an increased risk of neurological disorder where POI is due to premature menopause or induced from surgery. This increased risk appears to be most apparent on domains of global cognitive and verbal memory tests. Where POI is caused by genetic disorder, observed cognitive deficiencies may be more likely to have a genetic basis rather than being due to the effects of sex steroids on the brain. Findings related to loss of cognitive function after chemotherapy or GnRH treatments are mixed. There are also discrepant data related to use of hormone therapy after POI (particularly after surgical menopause). After surgery, hormone treatment appears to be most beneficial if initiated close to the average natural age of menopause.

History

School

  • Sport, Exercise and Health Sciences

Published in

Minerva Endocrinologica

Volume

39

Issue

3

Pages

189 - 199

Citation

SONI, M. and HOGERVORST, E., 2014. Premature ovarian insufficiency and neurological function. Minerva Endocrinologica, 39(3), pp. 189-199.

Publisher

Edizioni Minerva Medica

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2014

Notes

This paper is in closed access.

ISSN

0391-1977

eISSN

1827-1634

Language

en

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