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Preparation of biodegradable polymeric nanoparticles for pharmaceutical applications using glass capillary microfluidics

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journal contribution
posted on 18.08.2015, 15:44 by Rahimah Othman, Goran Vladisavljevic, Zoltan Nagy
The aim of this study was to develop a new microfluidic approach for the preparation of nanoparticles with tuneable sizes based on micromixing/direct nanoprecipitation in a coaxial assembly of tapered-end glass capillaries. The organic phase was 1 wt% poly(ε-caprolactone) (PCL) or poly(dl-lactic acid) (PLA) in tetrahydrofuran and the antisolvent was Milli-Q water. The size of nanoparticles was precisely controlled over a range of 190–650 nm by controlling phase flow rates, orifice size and flow configuration (two-phase co-flow or counter-current flow focusing). Smaller particles were produced in a flow focusing device, because the organic phase stream was significantly narrower than the orifice and remained narrow for a longer distance downstream of the orifice. The mean size of PCL particles produced in a flow focusing device with an orifice size of 200 μm, an organic phase flow rate of 1.7 mL h−1 and an aqueous-to-organic flow rate ratio of 10 was below 200 nm. The size of nanoparticles decreased with decreasing the orifice size and increasing the aqueous-to-organic phase flow rate ratio. Due to higher affinity for water and amorphous structure, PLA nanoparticles were smaller and exhibited a smoother surface and more rounded shape than PCL particles.

Funding

The authors gratefully acknowledge the financial support given for this work through the Ministry of Higher Education Malaysia. ZK Nagy would like to acknowledge financial support provided by the European Research Council Grant no. (280106-CrySys).

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Chemical Engineering Science

Volume

137

Pages

119 - 130

Citation

OTHMAN, R., VLADISAVLJEVIC, G.T. and NAGY, Z.K., 2015. Preparation of biodegradable polymeric nanoparticles for pharmaceutical applications using glass capillary microfluidics. Chemical Engineering Science, 137, pp. 119 - 130.

Publisher

© Elsevier

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2015

Notes

This paper was accepted for publication in the journal Chemical Engineering Science and the definitive published version is available at http://dx.doi.org/10.1016/j.ces.2015.06.025

ISSN

1873-4405

Language

en

Exports