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Prospective association of TV viewing with acute phase reactants and coagulation markers: English Longitudinal Study of Ageing

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journal contribution
posted on 28.10.2015 by Mark Hamer, Lee Smith, Emmanuel Stamatakis
Objective: Inflammatory processes are putative mechanisms underlying the detrimental health effects of sedentary behaviour but no long-term prospective data are available. We examined the longitudinal association between TV viewing, physical activity and inflammatory markers over a 4-year follow-up period. Methods: Participants were 3612 men and women (mean age 64.1 ± 8.2 years) from the English Longitudinal Study of Ageing. Self-reported daily TV viewing was measured at baseline and 2 years follow up. Inflammatory markers (serum high-sensitivity C-reactive protein [CRP], white blood cell count [WBC], and fibrinogen) were measured at baseline (2008/09) and 4 years follow-up (2012/13). Results: On average, participants viewed TV for 5.1 ± 4.0 h/d, and there was an increase of 1.9 h/wk TV viewing over 2 years. In linear models adjusted for covariates including physical activity, TV viewing was not associated with logeCRP at follow-up (B ¼ 0.004, 95% CI, 0.001, 0.009, p ¼ 0.09) but was associated with WBC (B ¼ 0.018, 95% CI, 0.005, 0.031, p ¼ 0.006), and fibrinogen (B ¼ 0.004, 95% CI, 0.00, 0.008, p ¼ 0.035). In contrast, physical activity was inversely associated with CRP (p ¼ 0.047) and WBC (p ¼ 0.026), but not fibrinogen (p ¼ 0.22). An increase in TV viewing (of at least 1 h/d) was associated with higher concentrations of CRP (p ¼ 0.015) and WBC (p ¼ 0.05) at follow up after adjustment for covariates and baseline TV viewing. Conclusions: Physical activity and sedentary behaviour have contrasting associations with markers of low grade inflammation over 4 years of follow-up. These behaviours may be important in influencing the pro-inflammatory state seen with ageing.

Funding

The funding is provided by the National Institute on Aging in the United States (grants 2RO1AG7644-01A1 and 2RO1AG017644) and a consortium of UK government departments coordinated by the Office for National Statistics. MH is supported by the British Heart Foundation (RE/10/005/28296). LS is supported by the National Institute for Health Research's School for Public Health Research.

History

School

  • Sport, Exercise and Health Sciences

Published in

Atherosclerosis

Citation

HAMER, M., SMITH, L. and STAMATAKIS, E., 2015. Prospective association of TV viewing with acute phase reactants and coagulation markers: English Longitudinal Study of Ageing. Atherosclerosis, 239 (2), pp. 322–327.

Publisher

© Elsevier Ireland Ltd.

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2015

Notes

This article was accepted for publication in the journal, Atherosclerosis [© Elsevier Ireland Ltd.] and the definitive version is available at: http://dx.doi.org/10.1016/j.atherosclerosis.2015.02.009

ISSN

1879-1484

Language

en

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