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Proteolysis, caloric restriction and aging

journal contribution
posted on 06.03.2015 by K. Merker, Alexandra Stolzing, Tilman Grune
The nature of the aging process has been the subject of considerable speculation. It is believed that free radical damage to cellular components is one of the main contributors to the aging process. Studies on proteins have shown age-related decline in enzyme activities, age-related accumulation of oxidized proteins and a decline of the proteolytic machinery of the cell. The proteasome, a highly regulated intracellular proteolytic system, is the major enzymatic system responsible for the degradation of damaged proteins. The current knowledge on regulation and of the properties of this unique proteolytic system with special emphasis to the aging process are discussed in this review. Since it is known that caloric restriction (CR) is the only method to delay the aging process and extend the maximal lifespan the effects of CR on the age-related decline in protein degradation is highlighted. © 2001 Published by Elsevier Science Ireland Ltd.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Mechanisms of Ageing and Development

Volume

122

Issue

7

Pages

595 - 615

Citation

MERKER, K., STOLZING, A. and GRUNE, T., 2001. Proteolysis, caloric restriction and aging. Mechanisms of Ageing and Development, 122 (7), pp. 595 - 615.

Publisher

© Elsevier Science Ireland Ltd.

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2001

Notes

This article is closed access.

ISSN

0047-6374

Language

en

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