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Pulse wave velocity is associated with increased plasma oxLDL in ageing but not with FGF21 and habitual exercise

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posted on 06.03.2020 by Shuen Yee Lee, Stephen F Burns, Kenneth KC Ng, David Stensel, Liang Zhong, Frankie HY Tan, Kar Ling Chia, Kai Deng Fam, Margaret MC Yap, Kwee Poo Yeo, Eric PH Yap, Chin Leong Lim
Fibroblast growth factor 21 (FGF21) and adiponectin increase expression of genes involved in antioxidant pathways, but their roles in mediating oxidative stress and arterial stiffness with ageing and habitual exercise remain unknown. We explored the role of the FGF21–adiponectin axis in mediating oxidative stress and arterial stiffness with ageing and habitual exercise. Eighty age- and sex-matched healthy individuals were assigned to younger sedentary or active (18–36 years old,n=20 each) and older sedentary or active (45–80 years old,n=20 each) groups. Arterial stiffness was measured indirectly using pulse wave velocity (PWV). Fasted plasma concentrations of FGF21, adiponectin and oxidized low-density lipoprotein (oxLDL) were measured. PWV was 0.2-fold higher and oxLDL concentration was 25.6% higher (both p<0.001) in older than younger adults, despite no difference in FGF21 concentration (p=0.097) between age groups. PWV (p=0.09) and oxLDL concentration (p=0.275) did not differ between activity groups but FGF21 concentration was 9% lower in active than sedentary individuals (p=0.011). Adiponectin concentration did not differ by age (p=0.642) or exercise habits (p=0.821). In conclusion, age, but not habitual exercise, was associated with higher oxidative stress and arterial stiffness. FGF21 and adiponectin did not differ between younger and older adults, unlikely mediating oxidative stress and arterial stiffness in healthy adults.

Funding

Ministry of Education Singapore Start-up Grant for Human and Metabolic disease (L0412270).

National Medical Research Council (NMRC/OFIRG/0018/2016)

History

School

  • Sport, Exercise and Health Sciences

Published in

Antioxidants

Volume

9

Issue

3

Publisher

MDPI AG

Version

VoR (Version of Record)

Rights holder

© the authors

Publisher statement

This is an Open Access Article. It is published by MDPI under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

Acceptance date

06/03/2020

Publication date

2020-03-07

Copyright date

2020

ISSN

2076-3921

Language

en

Depositor

Prof David Stensel Deposit date: 6 March 2020

Article number

221

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