Abou-El-Nein_20160429_Manuscript_Final.pdf (478 kB)

Putting a price tag on novel autologous cellular therapies

Download (478 kB)
journal contribution
posted on 07.07.2016 by Mohamed Abou-El-Enein, Gerhard Bauer, Nick Medcalf, Hans-Dieter Volk, Petra Reinke
Cell therapies, especially autologous therapies, pose significant challenges to researchers who wish to move from small, probably academic, methods of manufacture to full commercial scale. There is a dearth of reliable information about the costs of operation, and this makes it difficult to predict with confidence the investment needed to translate the innovations to the clinic, other than as small-scale, clinician-led prescriptions. Here, we provide an example of the results of a cost model that takes into account the fixed and variable costs of manufacture of one such therapy. We also highlight the different factors that influence the product final pricing strategy. Our findings illustrate the need for cooperative and collective action by the research community in pre-competitive research to generate the operational models that are much needed to increase confidence in process development for these advanced products.

Funding

This work was partially supported by a DFG-grant: SFB-TR36, project A2

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Cytotherapy

Citation

ABOU-EL-ENEIN, M. ... et al., 2016. Putting a price tag on novel autologous cellular therapies. Cytotherapy, 18 (8), pp. 1056–1061.

Publisher

© International Society for Cellular Therapy. Published by Elsevier Inc.

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

09/05/2016

Publication date

2016

Notes

This paper was accepted for publication in the journal Cytotherapy and the definitive published version is available at http://dx.doi.org/10.1016/j.jcyt.2016.05.005

ISSN

1465-3249

eISSN

1477-2566

Language

en

Exports