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Relating induction time and metastable zone width

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journal contribution
posted on 01.07.2019 by Huaiyu Yang, Alastair J. Florence
© 2017 The Royal Society of Chemistry. A relation between induction time and metastable zone width in cooling crystallization has been developed based on the correlation between temperature and supersaturation with the induction time in the classical nucleation theory. By this relation, the nucleation times in linear cooling experiments and the induction times at constant temperature can be estimated from each other, i.e. estimating metastable zone widths from experimental induction times or interfacial energy and the pre-exponential factor from metastable zone widths. Ascorbic-water system, with 120 induction times and 192 metastable zone widths determined, and several systems reported in the literature, have been investigated to compare the estimated values of metastable zone width/induction time with experimental values, respectively. The estimated metastable zone widths are fairly consistent with the experimental values. The differences between experimental literature values of metastable zone widths and the estimated values using the literature induction times range from 0.1 K to 10 K with an average of 2.5 K. For two systems (paracetamol in ethanol and salicylic acid in ethyl acetate), estimated and experimental results are of very good consistency with an average uncertainty of only about 5%. More accurate extrapolations of the induction times from metastable zone widths have been investigated. The potential utilities of this approach in crystallization research and process understanding are discussed.

Funding

We acknowledge the EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallization for funding, with grant ref: EP/I033459/1. W

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

CrystEngComm

Volume

19

Issue

28

Pages

3966 - 3978

Citation

YANG, H. and FLORENCE, A.J., 2017. Relating induction time and metastable zone width. CrystEngComm, 19(28), pp. 3966 - 3978.

Publisher

© Royal Society of Chemistry

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

13/06/2017

Publication date

2017

Notes

This paper was accepted for publication in the journal CrystEngComm and the definitive published version is available at https://doi.org/10.1039/c7ce00770a

eISSN

1466-8033

Language

en

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