Final accepted manuscript (with figure 1).pdf (253.18 kB)

Salivary SIgA responses to acute moderate-vigorous exercise in monophasic oral contraceptive users

Download (253.18 kB)
journal contribution
posted on 08.04.2015 by Harumi Hayashida, Nicola J. Dolan, Charlotte Hounsome, Nawal Alajmi, Nicolette Bishop
The purpose of this study was to examine the effect of oral contraceptive (OC) use on salivary secretory immunoglobulin A (SIgA) levels at rest and in response to an acute bout of moderate-vigorous exercise during two phases of the 4 week OC cycle corresponding to different phases of the synthetic menstrual cycle. Ten healthy active females completed a cycling at 70% V(・)O2peak for 45 min at two time points of an OC cycle: during the equivalent in time to the mid-follicular phase (day 8 ± 2) and the mid-luteal phase (day 20 ± 2). Timed unstimulated saliva samples were obtained before, immediately post exercise and 1 h post exercise and analyzed for salivary SIgA. Salivary SIgA secretion rate was 26 % (95% Confidence limits, CI, 6-46) lower at post-exercise compared with pre-exercise during the synthetic follicular phase (p = 0.019) but no differences were observed during the synthetic luteal trial. Saliva flow rate was 11% (95% CI, 8-30) lower at post-exercise compared with pre-exercise (main effect for time; p = 0.025). In conclusion, the pattern of salivary SIgA secretion rate response to moderate-vigorous exercise varies across the early and late phases of a monophasic OC cycle, with a transient reduction in salivary SIgA responses during the synthetic follicular phase. These findings indicate that monophasic OC use should be considered when assessing mucosal immune responses to acute exercise.



  • Sport, Exercise and Health Sciences

Published in

Applied Physiology, Nutrition, and Metabolism


HAYASHIDA, H. ... et al, 2015. Salivary SIgA responses to acute moderate-vigorous exercise in monophasic oral contraceptive users. Applied Physiology, Nutrition, and Metabolism, 40(9), pp.863-867.


NRC Research Press / © The Authors


AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at:

Publication date



This article was published in the journal Applied Physiology, Nutrition, and Metabolism. The definitive version is available from: