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Scanning the horizon for high value-add manufacturing science: Accelerating manufacturing readiness for the next generation of disruptive, high-value curative cell therapeutics

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journal contribution
posted on 18.01.2018 by Paul C. Hourd, David Williams
Since the Regenerative Medicine sector entered the second phase of its development (RegenMed 2.0) more than a decade ago, there is increasing recognition that current technology innovation trajectories will drive the next translational phase towards the production of disruptive, high value curative cell and gene based regenerative medicines. In this short report, a long lens look within the pluripotent stem cell therapeutic space, both embryonic and induced, is used to gain early insights on where critical technology and manufacturing challenges may emerge. The report offers a future perspective on the development and innovation that will be needed within manufacturing science to add value in the production and commercialisation of the next generation of advanced cell therapies and precision medicines.

Funding

The work described in this article was supported by the UK Regenerative Medicine Platform as part of the work of the Pluripotent Stem Cell Platform (Award MR/L012537/1) focussed on horizon scanning with respect to manufacturing.

History

School

  • Mechanical, Electrical and Manufacturing Engineering

Published in

Cytotherapy

Citation

HOURD, P.C. and WILLIAMS, D.J., 2018. Scanning the horizon for high value-add manufacturing science: Accelerating manufacturing readiness for the next generation of disruptive, high-value curative cell therapeutics. Cytotherapy, 20 (5), pp.759-767.

Publisher

Elsevier (© 2018 International Society for Cellular Therapy)

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/

Acceptance date

12/01/2018

Publication date

2018-04-16

Notes

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)

ISSN

1465-3249

Language

en

Licence

Exports