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Structured biodegradable polymeric microparticles for drug delivery produced using flow focusing glass microfluidic devices

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journal contribution
posted on 09.11.2015 by Ekanem Ekanem, Ali Nabavi, Goran Vladisavljevic, Sai Gu
Biodegradable poly(DL-lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) microparticles with tunable size, shape, internal structure and surface morphology were produced by counter-current flow focusing in axisymmetric (3D) glass capillary devices. The dispersed phase was composed of 0.5-2 wt% polymer solution in a volatile 2 organic solvent (ethyl acetate or dichloromethane) and the continuous phase was 5 wt% aqueous poly(vinyl alcohol) solution. The droplets with a coefficient of variation in dripping regime below 2.5 % were evaporated to form polymeric particles with uniform sizes ranging between 4-30 μm. The particle microstructure and surface roughness were modified by adding nanofiller (montmorillonite nanoclay) or porogen (2-methylpentane) in the dispersed phase to form less porous polymer matrix or porous particles with golf-ball-like dimpled surface, respectively. The presence of 2-4 wt% nanoclay in the host polymer significantly reduced the release rate of paracetamol and prevented the early burst release, as a result of reduced polymer porosity and tortuous path for the diffusing drug molecules. Numerical modelling results using the volume of fluid-continuum surface force model agreed well with experimental behaviour and revealed trapping of nanoclay particles in the dispersed phase upstream of the orifice at low dispersed phase flow rates and for 4 wt% nanoclay content, due to vortex formation. Janus PLA/PCL (polycaprolactone) particles were produced by solvent evaporation-induced phase separation within organic phase droplets containing 3 % (v/v) PLA/PCL (30/70 or 70/30) mixture in dichloromethane. A strong preferential adsorption of Rhodamine 6G dye onto PLA was utilized to identify PLA portions of the Janus particles by Confocal Laser Scanning Microscopy (CLSM). Uniform hemispherical PCL particles were produced by dissolution of PLA domes with acetone.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

ACS Applied Materials & Interfaces

Pages

151001053821009 - 151001053821009

Citation

EKANEM, E.E. ...et al., 2015. Structured biodegradable polymeric microparticles for drug delivery produced using flow focusing glass microfluidic devices. ACS Applied Materials & Interfaces, 7(41), pp 23132–23143.

Publisher

© American Chemical Society

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2015

Notes

This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acsami.5b06943

ISSN

1944-8244

eISSN

1944-8252

Language

en

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