J. Biol. Chem.-2018-Anderson-jbc.TM117.000368.pdf (912.44 kB)

Synthetic biology strategies for improving microbial synthesis of "green" biopolymers

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journal contribution
posted on 03.07.2018 by Lisa A. Anderson, Ahsan Islam, Kristala L. Prather
Polysaccharide-based biopolymers have many material properties relevant to industrial and medical uses, including as drug delivery agents, wound-healing adhesives, and food additives and stabilizers. Traditionally, polysaccharides are obtained from natural sources. Microbial synthesis offers an attractive alternative for sustainable production of tailored biopolymers. Here, we review synthetic biology strategies for select “green” biopolymers: cellulose, alginate, chitin, chitosan, and hyaluronan. Microbial production pathways, opportunities for pathway yield improvements, and advances in microbial engineering of biopolymers in various hosts are discussed. Taken together, microbial engineering has expanded the repertoire of green biological chemistry by increasing the diversity of biobased materials.

Funding

This work was supported by the National Institute of General Medical Sciences (NIGMS, Grant P50 GM098792) and the National Science Foundation (NSF, Grant MCB-1517913).

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

JOURNAL OF BIOLOGICAL CHEMISTRY

Volume

293

Issue

14

Pages

5053 - 5061

Citation

ANDERSON, L.A., ISLAM, M.A. and PRATHER, K.L., 2018. Synthetic biology strategies for improving microbial synthesis of "green" biopolymers. Journal of Biological Chemistry, 293 (14), pp.5053-5061.

Publisher

© The American Society for Biochemistry and Molecular Biology, Inc.

Version

AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2018-01-16

Notes

This research was originally published in the Journal of Biological Chemistry. Lisa A. Anderson, M. Ahsanul Islam, and Kristala L. J. Prather. Synthetic biology strategies for improving microbial synthesis of "green" biopolymers. J. Biol. Chem. 2018; 293:pp5053-pp5061. © the American Society for Biochemistry and Molecular Biology.

ISSN

0021-9258

eISSN

1083-351X

Language

en

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