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Tempe, tofu, and amyloid-β 1-40 serum levels in ovariectomized rats

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journal contribution
posted on 16.07.2020 by Atik Kridawati, Hardinsyah Hardinsyah, Ahmad Sulaeman, Tri Budi W Rahardjo, Eef Hogervorst
BACKGROUND: Estrogens have been found to reduce amyloid-β (Aβ) levels, a risk factor associated with dementia. We hypothesized that phytoestrogenic soybean products such as tempe and tofu might show similar effects. OBJECTIVE: The aims of this study were to analyze the effect of tempe and tofu flour on Aβ1-40 serum levels in elderly rats. METHODS: This research was conducted on female Sprague Dawley rats, aged 12 months. Before the intervention rats underwent ovariectomy (OVx) and were grouped into 5 intervention groups which were given tempe flour, tofu flour, estradiol, or casein as an active control. There was also a non-OVx control group which was fed a normal diet. RESULTS: The intake of tempe and tofu flour decreased Aβ serum levels in all estrogen and phytoestrogenic treatment groups, offsetting effects of OVx (but not in the casein group, where Aβ levels rise). CONCLUSION: The tempe flour group showed the strongest decrease in serum Aβ levels compared to the other groups. Future studies should investigate whether tempe can reduce Aβ levels in patients with dementia.

History

School

  • Sport, Exercise and Health Sciences

Published in

Journal of Alzheimer's Disease

Volume

76

Issue

1

Pages

159-163

Publisher

IOS

Version

AM (Accepted Manuscript)

Rights holder

© IOS Press and the authors

Publisher statement

The final publication is available at IOS Press through https://doi.org/10.3233/JAD-200220

Acceptance date

13/04/2020

Publication date

2020-06-30

Copyright date

2020

eISSN

1875-8908

Language

en

Depositor

Prof Eef Hogervorst. Deposit date: 14 July 2020

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