MRS_Prospective_final_unsubmitted.pdf (1.02 MB)
0/0

The need for advanced three-dimensional neural models and developing enabling technologies

Download (1.02 MB)
journal contribution
posted on 01.10.2018 by Daniel Merryweather, Paul Roach
Neurological and psychiatric disorders account for an increasing proportion of the global disease burden. Correspondingly the neuropharmaceutical industry has experienced a significant contraction in recent years resulting in a poor variety of therapies available to treat an expanding range of conditions. Perhaps the greatest contributor to this failure in drug-discovery is the lack of understanding of the underlying biology of the nervous system and how molecular scale events translate into macroscale pathologies. Due to the unique nature of the human nervous system commonly used model organisms are often poorly representative of human pathologies resulting in a need for the development of advanced in vitro models that are capable of faithfully modeling complex structures within the brain. In this prospective, strategies for the generation of neuronal circuits and cultivation of complex three-dimensional (3D) cultures are explored. Frequently these constructs provide valuable insights into systems and processes that are difficult to explore in vivo due to the isolated and delicate nature of neuronal tissues. New developments are required to assess the physiological functions of 3D tissues in vitro.

History

School

  • Science

Department

  • Chemistry

Published in

MRS Communications

Volume

7

Issue

03

Pages

309 - 319

Citation

MERRYWEATHER, D. and ROACH, P., 2017. The need for advanced three-dimensional neural models and developing enabling technologies. MRS Communications, 7 (3), pp.309-319.

Publisher

Cambridge University Press © Materials Research Society

Version

AM (Accepted Manuscript)

Publication date

2017-07-10

Notes

This article has been published in a revised form in MRS Communications https://doi.org/10.1557/mrc.2017.50. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © Materials Research Society.

ISSN

2159-6859

eISSN

2159-6867

Language

en

Exports

Logo branding

Keyword(s)

Exports