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The unaided recovery of marathon-induced serum metabolome alterations

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journal contribution
posted on 07.07.2020 by Zinandré Stander, Laneke Luies, Lodewyk J Mienie, Mari Van Reenen, Glyn Howatson, Karen M Keane, Tom Clifford, Emma J Stevenson, Du Toit Loots
Endurance athlete performance is greatly dependent on sufcient post-race system recovery, as endurance races have substantial physiological, immunological and metabolic efects on these athletes. To date, the efects of numerous recovery modalities have been investigated, however, very limited literature exists pertaining to metabolic recovery of athletes after endurance races without the utilisation of recovery modalities. As such, this investigation is aimed at identifying the metabolic recovery trend of athletes within 48 h after a marathon. Serum samples of 16 athletes collected 24 h before, immediately after, as well as 24 h and 48 h post-marathon were analysed using an untargeted two-dimensional gas chromatography time-of-fight mass spectrometry metabolomics approach. The metabolic profles of these comparative time-points indicated a metabolic shift from the overall post-marathon perturbed state back to the pre-marathon metabolic state during the recovery period. Statistical analyses of the data identifed 61 signifcantly altered metabolites including amino acids, fatty acids, tricarboxylic acid cycle, carbohydrates and associated intermediates. These intermediates recovered to pre-marathon related concentrations within 24 h post-marathon, except for xylose which only recovered within 48 h. Furthermore, fuctuations in cholesterol and pyrimidine intermediates indicated the activation of alternative recovery mechanisms. Metabolic recovery of the athletes was attained within 48 h post-marathon, most likely due to reduced need for fuel substrate catabolism. This may result in the activation of glycogenesis, uridine-dependent nucleotide synthesis, protein synthesis, and the inactivation of cellular autophagy. These results may be benefcial in identifying more efcient, targeted recovery approaches to improve athletic performance.

Funding

National Research Foundation of South Africa (Grant Nos. 116703, 120358).

History

School

  • Sport, Exercise and Health Sciences

Published in

Scientific Reports

Volume

10

Issue

1

Pages

11060

Publisher

Springer Science and Business Media LLC

Version

VoR (Version of Record)

Rights holder

© The authors

Publisher statement

This is an Open Access Article. It is published by Springer under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

Acceptance date

02/06/2020

Publication date

2020-07-06

Copyright date

2020

eISSN

2045-2322

Language

en

Depositor

Dr Tom Clifford Deposit date: 6 July 2020

Article number

11060

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