Paper_5_13_Das.pdf (477.15 kB)
0/0

Transdermal drug delivery by coated microneedles: geometry effects on drug concentration in blood

Download (477.15 kB)
journal contribution
posted on 12.03.2010 by Barrak Al-Qallaf, Diganta Das, Adam Davidson
Drug administration through transdermal delivery is restricted by the top layer of skin, the stratum corneum. One possible solution to overcome the barrier function of the stratum corneum is to employ microneedle arrays. However, detailed theoretical models relating drugcoated microneedles and their geometry to the drug concentration in the blood are limited. This paper aims to address this issue by examining the blood concentration profiles for a model drug, insulin, that has been administered via coated microneedles. A mathematical model is introduced and applied to predict theoretical blood concentrations. Furthermore, the insulin concentration in blood is calculated for a range of different microneedle shapes and dimensions to identify the most effective geometry. The results indicate that the optimum mic r2o0needle geometry in terms of maximimizing insulin concentration was a rocket shaped needle that has a constant tip angle of 90º. Also, it has been found that the number of microneedles in an array is the most significant factor in determining maximum insulin concentration in the blood (Cb,max).

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Citation

AL-QALLAF, B., DAS, D.B. and DAVIDSON, A., 2009. Transdermal drug delivery by coated microneedles: geometry effects on drug concentration in blood. Asia-Pacific Journal of Chemical Engineering, 4 (6), pp.845-857.

Publisher

© Curtin University of Technology and John Wiley & Sons Ltd.

Version

SMUR (Submitted Manuscript Under Review)

Publication date

2009

Notes

This is the pre-peer reviewed version of the following article: AL-QALLAF, B., DAS, D.B. and DAVIDSON, A., 2009. Transdermal drug delivery by coated microneedles: geometry effects on drug concentration in blood. Asia-Pacific Journal of Chemical Engineering, 4 (6), pp.845-857, which has been published in final form at http://dx.doi.org/10.1002/apj.353

ISSN

1932-2135

Language

en

Exports