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Transdermal drug delivery by coated microneedles : geometry effects on effective skin thickness and drug permeability

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journal contribution
posted on 12.01.2009 by Adam Davidson, Barrak Al-Qallaf, Diganta Das
Although transdermal drug delivery has been used for about three decades, the range of therapeutics that are administered this way is limited by the barrier function of the stratum corneum (the top layer of skin). Microneedle arrays have been shown to increase the drug permeability in skin by several orders of magnitude by bypassing the stratum corneum. This 15 can potentially allow the transdermal delivery of many medicaments including large macromolecules that typically cannot diffuse through the skin. This paper addresses the use of microneedles coated with a drug solution film. In particular, we identify how the geometries of various microneedles affect the drug permeability in skin. Effective skin permeability is calculated for a range of microneedle shapes and dimensions in order to identify the most 20 efficient geometry. To calculate effective permeability (Peff), the effective skin thickness (Heff) is calculated. These are then plotted for insulin as a model drug to see how various microneedle parameters affect the profiles of both Heff and Peff. It is found that the depth of penetration from the microneedle array is the most important factor in determining Peff, followed by the microneedle spacings. Other parameters such as microneedle diameter and 25 coating depth are less significant.

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Citation

DAVIDSON, A., AL-QALLAF, B. DAS, D.B., 2008. Transdermal drug delivery by coated microneedles : geometry effects on effective skin thickness and drug permeability. Chemical Engineering Research and Design, 86 (11), pp. 1196-1206

Publisher

Elsevier Ltd (© The Institution of Chemical Engineers)

Version

AM (Accepted Manuscript)

Publication date

2008

Notes

This article was published in the journal, Chemical Engineering Research and Design [Elsevier / © The Institution of Chemical Engineers] and the definitive version is available at: www.elsevier.com/locate/cherd

ISSN

0263-8762

Language

en

Exports