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Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality.

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posted on 02.10.2018 by Shabina A. Hayat, Robert Luben, Nichola Dalzell, Stephanie Moore, Eef Hogervorst, Fiona E. Matthews, Nick Wareham, Carol Brayne, Kay-Tee Khaw
Despite several studies demonstrating an independent and inverse association between cognition and mortality, the nature of this association still remains unclear. To examine the association of cognition and mortality after accounting for sociodemographic, health and lifestyle factors and to explore both test and population characteristics influencing this relationship. In a population based cohort of 8585 men and women aged 48-92 years, who had cognitive assessments in 2006-2011 and were followed up till 2016 for mortality, we examined the relationship between individual cognitive tests as well as a global cognition score to compare their ability in predicting mortality and whether these differed by population characteristics. Risk of death was estimated using Cox proportional hazard regression models including sociodemographic, lifestyle and health variables, and self-reported comorbidities, as covariates in the models. Poor cognitive performance (bottom quartile of combined cognition score) was associated with higher risk of mortality, Hazard Ratio = 1.32 (95% Confidence Interval 1.09, 1.60); individual cognitive tests varied in their mortality associations and also performed differently in middle-age and older age groups. Poor cognitive performance is independently associated with higher mortality. This association is observed for global cognition and for specific cognitive abilities. Associations vary depending on the cognitive test (and domain) as well as population characteristics, namely age and education.

Funding

This work was supported by the Medical Research Council, UK http://www.mrc.ac.uk/ (Ref: G0401527) and Cancer Research UK http://www.cancerresearchuk. org/(CRUK, Ref: C864/A8257)

History

School

  • Sport, Exercise and Health Sciences

Published in

Eur J Epidemiol

Citation

HAYAT, S.A. ... et al., 2018. Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality. Netherlands, European Journal of Epidemiology, doi: 10.1007/s10654-018-0439-z

Publisher

© the Authors. Published by Springer

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/

Acceptance date

29/08/2018

Publication date

2018

Notes

This is an Open Access Article. It is published by Springer under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

ISSN

0393-2990

eISSN

1573-7284

Language

en

Location

Netherlands

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