PLOS-OA-Version.pdf (681.07 kB)
0/0

Using mathematical modelling to explore hypotheses about the role of bovine epithelium structure in foot-and-mouth disease virus-induced cell lysis

Download (681.07 kB)
journal contribution
posted on 11.11.2015 by Kyriaki Giorgakoudi, Simon Gubbins, John Ward, Nicholas Juleff, Zhidong Zhang, David Schley
Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals. FMD virus (FMDV) shows a strong tropism for epithelial cells, and FMD is characterised by cell lysis and the development of vesicular lesions in certain epithelial tissues (for example, the tongue). By contrast, other epithelial tissues do not develop lesions, despite being sites of viral replication (for example, the dorsal soft palate). The reasons for this di erence are poorly understood, but hypotheses are di cult to test experimentally. In order to identify the factors which drive cell lysis, and consequently determine the development of lesions, we developed a partial di erential equation model of FMDV infection in bovine epithelial tissues and used it to explore a range of hypotheses about epithelium structure which could be driving di erences in lytic behaviour observed in di erent tissues. Our results demonstrate that, based on current parameter estimates, epithelial tissue thickness and cell layer structure are unlikely to be determinants of FMDV-induced cell lysis. However, di erences in receptor distribution or viral replication amongst cell layers could in uence the development of lesions, but only if viral replication rates are much lower than current estimates.

Funding

This work was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) [grant code: BBS/E/I/00001397].

History

School

  • Science

Department

  • Mathematical Sciences

Published in

PLOS ONE

Volume

10

Issue

10

Pages

? - ? (21)

Citation

GIORGAKOUDI, K. ... et al, 2015. Using mathematical modelling to explore hypotheses about the role of bovine epithelium structure in foot-and-mouth disease virus-induced cell lysis. PLOS ONE, 10(10): e0138571

Publisher

Public Library of Science (PLOS) / © 2015 Giorgakoudi et al.

Version

VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/ by/4.0/

Publication date

2015

Notes

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ISSN

1932-6203

Language

en

Licence

Exports