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3D-printable zwitterionic nano-composite hydrogel system for biomedical applications

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journal contribution
posted on 2020-12-10, 15:38 authored by Nathalie Sallstrom, Andrew CapelAndrew Capel, Mark LewisMark Lewis, Daniel Engstrom, Simon MartinSimon Martin
Herein, the cytotoxicity of a novel zwitterionic sulfobetaine hydrogel system with a nano-clay crosslinker has been investigated. We demonstrate that careful selection of the composition of the system (monomer to Laponite content) allows the material to be formed into controlled shapes using an extrusion based additive manufacturing technique with the ability to tune the mechanical properties of the product. Moreover, the printed structures can support their own weight without requiring curing during printing which enables the use of a printing-then-curing approach. Cell culture experiments were conducted to evaluate the neural cytotoxicity of the developed hydrogel system. Cytotoxicity evaluations were conducted on three different conditions; a control condition, an indirect condition (where the culture medium used had been in contact with the hydrogel to investigate leaching) and a direct condition (cells growing directly on the hydrogel). The result showed no significant difference in cell viability between the different conditions and cells were also found to be growing on the hydrogel surface with extended neurites present.

Funding

EPSRC Centre for Doctoral Training in Additive Manufacturing and 3D Printing

Engineering and Physical Sciences Research Council

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History

School

  • Mechanical, Electrical and Manufacturing Engineering
  • Sport, Exercise and Health Sciences

Published in

Journal of Tissue Engineering

Volume

11

Pages

1 - 11

Publisher

Sage

Version

  • VoR (Version of Record)

Rights holder

© The authors

Publisher statement

This is an Open Access Article. It is published by Sage under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/

Acceptance date

2020-09-29

Publication date

2020-10-29

Copyright date

2020

ISSN

2041-7314

Language

  • en

Depositor

Miss Nathalie Sallstrom. Deposit date: 8 December 2020

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