Sallstrom_2041731420967294.pdf (1.21 MB)
Download file3D-printable zwitterionic nano-composite hydrogel system for biomedical applications
journal contribution
posted on 2020-12-10, 15:38 authored by Nathalie Sallstrom, Andrew CapelAndrew Capel, Mark LewisMark Lewis, Daniel EngstromDaniel Engstrom, Simon MartinSimon MartinHerein, the cytotoxicity of a novel zwitterionic sulfobetaine hydrogel system with a nano-clay crosslinker has been
investigated. We demonstrate that careful selection of the composition of the system (monomer to Laponite content)
allows the material to be formed into controlled shapes using an extrusion based additive manufacturing technique
with the ability to tune the mechanical properties of the product. Moreover, the printed structures can support their
own weight without requiring curing during printing which enables the use of a printing-then-curing approach. Cell
culture experiments were conducted to evaluate the neural cytotoxicity of the developed hydrogel system. Cytotoxicity
evaluations were conducted on three different conditions; a control condition, an indirect condition (where the culture
medium used had been in contact with the hydrogel to investigate leaching) and a direct condition (cells growing directly
on the hydrogel). The result showed no significant difference in cell viability between the different conditions and cells
were also found to be growing on the hydrogel surface with extended neurites present.
Funding
EPSRC Centre for Doctoral Training in Additive Manufacturing and 3D Printing
Engineering and Physical Sciences Research Council
Find out more...History
School
- Mechanical, Electrical and Manufacturing Engineering
- Sport, Exercise and Health Sciences
Published in
Journal of Tissue EngineeringVolume
11Pages
1 - 11Publisher
SageVersion
- VoR (Version of Record)
Rights holder
© The authorsPublisher statement
This is an Open Access Article. It is published by Sage under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/Acceptance date
2020-09-29Publication date
2020-10-29Copyright date
2020ISSN
2041-7314Publisher version
Language
- en