1-s2.0-S0169409X21001125-main.pdf (904.49 kB)
Download file

A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos

Download (904.49 kB)
journal contribution
posted on 27.04.2021, 07:44 by Stephanie Rankin-Turner, Pieter Vader, Lorraine O’Driscoll, Bernd Giebel, Liam HeaneyLiam Heaney, Owen DaviesOwen Davies
Extracellular vesicles (EVs) are complex nanoparticles required for the intercellular transfer of diverse biological cargoes. Unlike synthetic nanoparticles, EVs may provide a natural platform for the enhanced targeting and functional transfer of therapeutics across complex and often impenetrable biological boundaries (e.g. the blood–brain barrier or the matrix of densely organised tumours). Consequently, there is considerable interest in utilising EVs as advanced drug delivery systems for the treatment of a range of challenging pathologies. Within the past decade, efforts have focused on providing standard minimal requirements for conducting basic EV research. However, no standard reporting framework has been established governing the therapeutic loading of EVs for drug delivery applications. The purpose of this review is to critically evaluate progress in the field, providing an initial set of guidelines that can be applied as a benchmark to enhance reproducibility and increase the likelihood of translational outcomes.

Funding

Academy of Medical Sciences Springboard award and Partnership for Clean Competition grant.

European Research Council (ERC) (Starting Grant, # 851936).

History

School

  • Sport, Exercise and Health Sciences

Published in

Advanced Drug Delivery Reviews

Volume

173

Pages

479-491

Publisher

Elsevier BV

Version

VoR (Version of Record)

Rights holder

© The Authors

Publisher statement

This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution 4.0 International Licence (CC BY 4.0). Full details of this licence are available at: https://creativecommons.org/licenses/by/4.0/

Acceptance date

09/04/2021

Publication date

2021-04-20

Copyright date

2021

ISSN

0169-409X

Language

en

Depositor

Dr Owen Davies. Deposit date: 26 April 2021