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A cost-effective analysis of the CYCLE-HD randomized controlled trial

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posted on 03.06.2021, 11:23 by Daniel S. March, Adam W Hurt, Charlotte E Grantham, Darren R. Churchward, Hannah ML Young, Patrick J. Highton, Maurice Dungey, Nicolette BishopNicolette Bishop, Alice C. Smith, Matthew PM Graham-Brown, Nicola J. Cooper, James O. Burton
Introduction: No formal cost-effectiveness analysis has been performed for programs of cycling exercise during dialysis (intradialytic cycling [IDC]). The objective of this analysis is to determine the effect of a 6-month program of IDC on health care costs. Methods: This is a retrospective formal cost-effectiveness analysis of adult participants with end-stage kidney disease undertaking in-center maintenance hemodialysis enrolled in the CYCLE-HD trial. Data on hospital utilization, primary care consultations, and prescribed medications were extracted from medical records for the 6 months before, during, and after a 6-month program of thrice-weekly IDC. The cost-effectiveness analysis was conducted from a health care service perspective and included the cost of implementing the IDC intervention. The base-case analyses included a 6-month “within trial” analysis and a 12-month “within and posttrial” analysis considering health care utilization and quality of life (QoL) outcomes. Results: Data from the base-case within trial analysis, based on 109 participants (n = 56 control subjects and n = 53 IDC subjects) showed a reduction in health care utilization costs between groups, favoring the IDC group, and a 73% chance of IDC being cost-effective compared with control subjects at a willingness to pay of £20,000 and £30,000 per quality-adjusted life year (QALY) gained. When QoL data points were extrapolated forward to 12 months, the probability of IDC being cost-effective was 93% and 94% at £20,000 and £30,000 per QALY gained. Sensitivity analysis broadly confirms these findings. Conclusion: A 6-month program of IDC is cost-effective and the implementation of these programs nationally should be a priority.

Funding

StoneygateTrust

History

School

  • Sport, Exercise and Health Sciences

Published in

Kidney International Reports

Volume

6

Issue

6

Pages

1548-1557

Publisher

Elsevier

Version

VoR (Version of Record)

Rights holder

© 2021 International Society of Nephrology

Publisher statement

This is an Open Access Article. It is published by Elsevier under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Acceptance date

22/02/2021

Publication date

2021-04-08

Copyright date

2021

ISSN

2468-0249

Language

en

Depositor

Prof Lettie Bishop. Deposit date: 2 June 2021